Roles of phospholipase D in apoptosis and pro-survival

被引:60
作者
Nozawa, Y [1 ]
机构
[1] Gifu Int, Dept Environm Cell Respones, Inst Biotechnol, Gifu 5050116, Japan
来源
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | 2002年 / 1585卷 / 2-3期
基金
日本科学技术振兴机构;
关键词
phospholipase D (PLD); apoptosis; survival; lipid signaling;
D O I
10.1016/S1388-1981(02)00327-X
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Accumulating evidence has recognized phospholipase D (PLD) as an important element in signal transduction of cell responses, including proliferation and differentiation, However, its role in pro-apoptotic, anti-apoptotic or pro-survival signaling is not well-understood. Involvement of PLD in these signaling mechanisms is considered to differ depending on the cell type and the extracellular stimulus. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:77 / 86
页数:10
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