A transcriptional profile of aging in the human kidney

被引：247

作者：

Rodwell, GEJ

Sonu, R

Zahn, JM

Lund, J

Wilhelmy, J

Wang, LL

Xiao, WZ

Mindrinos, M

Crane, E

Segal, E

Myers, BD

Brooks, JD

Davis, RW

Higgins, J

Owen, AB

Kim, SK ^{[1
]}

机构：

[1] Stanford Univ, Med Ctr, Dept Dev Biol, Stanford, CA 94305 USA

[2] Stanford Univ, Med Ctr, Div Nephrol, Stanford, CA 94305 USA

[3] Stanford Univ, Med Ctr, Dept Biochem, Stanford, CA 94305 USA

[4] Stanford Univ, Med Ctr, Dept Pathol, Stanford, CA 94305 USA

[5] Stanford Univ, Med Ctr, Dept Comp Sci, Stanford, CA 94305 USA

[6] Stanford Univ, Med Ctr, Dept Urol, Stanford, CA 94305 USA

[7] Stanford Univ, Med Ctr, Dept Genet, Stanford, CA 94305 USA

[8] Stanford Univ, Med Ctr, Dept Stat, Stanford, CA 94305 USA

来源：

PLOS BIOLOGY | 2004年 / 2卷 / 12期

关键词：

D O I：

10.1371/journal.pbio.0020427

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this study, we found 985 genes that change expression in the cortex and the medulla of the kidney with age. Some of the genes whose transcripts increase in abundance with age are known to be specifically expressed in immune cells, suggesting that immune surveillance or inflammation increases with age. The age-regulated genes show a similar aging profile in the cortex and the medulla, suggesting a common underlying mechanism for aging. Expression profiles of these age-regulated genes mark not only age, but also the relative health and physiology of the kidney in older individuals. Finally, the set of aging-regulated kidney genes suggests specific mechanisms and pathways that may play a role in kidney degeneration with age.

引用

页码：2191 / 2201

页数：11

共 25 条

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