The serotonergic modulation of synaptic plasticity in the rat hippocampo-medial prefrontal cortex pathway

被引：38

作者：

Ohashi, S ^{[1
]}

Matsumoto, M ^{[1
]}

Togashi, H ^{[1
]}

Ueno, KI ^{[1
]}

Yoshioka, M ^{[1
]}

机构：

[1] Hokkaido Univ, Grad Sch Med, Dept Pharmacol, Kita Ku, Sapporo, Hokkaido 0608638, Japan

来源：

NEUROSCIENCE LETTERS | 2003年 / 342卷 / 03期

关键词：

serotonin; 5,7-dihydroxytryptamine; hippocampo-medial prefrontal cortex pathway; synaptic plasticity; long-term potentiation; paired-pulse facilitation;

D O I：

10.1016/S0304-3940(03)00293-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

The ability of the serotonergic (5-HTergic) system to affect the hippocampo-medial prefrontal cortex (mPFC) synaptic properties was examined in rats with lesions of 5-HTergic neurons. Intracerebroventricular injections of 5,7-dihydroxytryptamine (5,7-DHT) resulted in selective depletion of 5-HT and 5-hydroxyindoleacetic acid in the cerebral cortex, hippocampus and raphe regions. The 5,7-DHT-lesioned rat had no changes in basal synaptic transmission in the hippocampo-mPFC pathway. Conversely, we observed the augmentation of short-term synaptic plasticity, i.e. paired-pulse facilitation, when compared with sham-operated rats in this pathway. The magnitude of long-term potentiation (LTP) was significantly augmented in 5,7-DHT-lesioned rats. This augmentation of hippocampo-mPFC LTP had a significant correlation with the degree of cortical 5-HT levels. These results suggest that the 5-HTergic system may modulate plastic properties at the hippocampal-mPFC synapses in vivo. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：179 / 182

页数：4

共 20 条

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AUTORADIOGRAPHIC ANALYSIS OF DIFFERENTIAL ASCENDING PROJECTIONS OF DORSAL AND MEDIAN RAPHE NUCLEI IN RAT [J].