Chemical and physiologic brain imaging in schizophrenia

被引：29

作者：

McClure, RJ ^{[1
]}

Keshavan, MS ^{[1
]}

Pettegrew, JW ^{[1
]}

机构：

[1] Univ Pittsburgh, Med Ctr, Western Psychiat Inst & Clin, Dept Psychiat, Pittsburgh, PA 15213 USA

来源：

PSYCHIATRIC CLINICS OF NORTH AMERICA | 1998年 / 21卷 / 01期

关键词：

D O I：

10.1016/S0193-953X(05)70363-4

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Technologic advances in functional brain imaging have provided exciting and informative insights into the functional neuroanatomy and neurochemistry of schizophrenia. Using MR spectroscopy, it has been possible to examine in vivo brain metabolism and to relate observed changes to physiological processes occurring at a cellular level. Positron emission tomography and single photon emission computed tomography have revealed disturbances of cerebral blood flow and glucose metabolism in patients with schizophrenia. More recently, these tools have also proved most useful in studying the relative receptor occupancy of typical and atypical antipsychotic medications.

引用

页码：93 / +

页数：32

共 194 条

[11] N-ACETYL-L-ASPARTIC ACID - A LITERATURE-REVIEW OF A COMPOUND PROMINENT IN H-1-NMR SPECTROSCOPIC STUDIES OF BRAIN [J].

BIRKEN, DL ;

OLDENDORF, WH .

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 1989, 13 (01) :23-31

[12]

Bolinger Lizann, 1992, V11, P1

[13]

BOURGEOIS JP, 1993, J NEUROSCI, V13, P2801

[14] SYNAPTOGENESIS IN THE PREFRONTAL CORTEX OF RHESUS-MONKEYS [J].

BOURGEOIS, JP ;

GOLDMANRAKIC, PS ;

RAKIC, P .

CEREBRAL CORTEX, 1994, 4 (01) :78-96

[15]

BREIER A, 1992, ARCH GEN PSYCHIAT, V49, P921

[16]

BROWN R, 1986, ARCH GEN PSYCHIAT, V43, P36

[17] DEVELOPMENTAL-CHANGES OF PHOSPHORUS METABOLITE CONCENTRATIONS IN THE HUMAN BRAIN - A P-31 MAGNETIC-RESONANCE SPECTROSCOPY STUDY IN-VIVO [J].

BUCHLI, R ;

MARTIN, E ;

BOESIGER, P ;

RUMPEL, H .

PEDIATRIC RESEARCH, 1994, 35 (04) :431-435

[18] THE FRONTAL LOBES, BASAL GANGLIA, AND TEMPORAL LOBES AS SITES FOR SCHIZOPHRENIA [J].

BUCHSBAUM, MS .

SCHIZOPHRENIA BULLETIN, 1990, 16 (03) :379-389

[19] FUNCTIONAL AND ANATOMICAL BRAIN IMAGING - IMPACT ON SCHIZOPHRENIA RESEARCH [J].

BUCHSBAUM, MS ;

HAIER, RJ .

SCHIZOPHRENIA BULLETIN, 1987, 13 (01) :115-+

[20] GLUCOSE METABOLIC-RATE IN NORMALS AND SCHIZOPHRENICS DURING THE CONTINUOUS PERFORMANCE-TEST ASSESSED BY POSITRON EMISSION TOMOGRAPHY [J].

BUCHSBAUM, MS ;

NUECHTERLEIN, KH ;

HAIER, RJ ;

WU, J ;

SICOTTE, N ;

HAZLETT, E ;

ASARNOW, R ;

POTKIN, S ;

GUICH, S .

BRITISH JOURNAL OF PSYCHIATRY, 1990, 156 :216-227

← 1 2 3 4 5 6 7 8 9 10 →