Anticancer activity of osmium metalla-rectangles

被引：42

作者：

Barry, Nicolas P. E. ^{[1
]}

Edafe, Fabio ^{[2
]}

Dyson, Paul J. ^{[2
]}

Therrien, Bruno ^{[1
]}

机构：

[1] Univ Neuchatel, Inst Chem, CH-2000 Neuchatel, Switzerland

[2] Ecole Polytech Fed Lausanne, Inst Sci & Ingn Chim, CH-1015 Lausanne, Switzerland

来源：

DALTON TRANSACTIONS | 2010年 / 39卷 / 11期

关键词：

ARENE RUTHENIUM COMPLEXES; PLATINUM; DRUGS; REACTIVITY; BINDING;

D O I：

10.1039/b925015h

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A series of cationic metalla-rectangles of the general formula [(p-cymene)(4)Os-4(OO boolean AND OO)(2)(N boolean AND N)(2)](4+) have been obtained in methanol from the dinuclear arene osmium precursors [(p-cymene)(2)Os-2(OO boolean AND OO)(2)Cl-2] (OO boolean AND OO = 2,5-dioxydo-1,4-benzoquinonato (dhbq), 2,5-dichloro-1,4-benzoquinonato (dcbq)) by reaction with bipyridine linkers (N boolean AND N = 4,4'-bipyridine, 1,2-bis(4-pyridyl)ethylene) in the presence of AgCF3SO3. All complexes were isolated as triflate salts and characterised by NMR, IR and UV-visible spectroscopy. The cytotoxicities of the dinuclear and tetranuclear osmium complexes were established using ovarian A2780 cancer cell lines. The most active metalla-rectangle, [(p-cymene)(4)Os-4(dhbq)(2)(4,4'-bipyridine)(2)](4+), shows an IC50 value of 5.7 mu M (comparable to cisplatin) against A2780 cancer cells and 7.5 mu M against the cisplatin resistant A2780cisR cells.

引用

页码：2816 / 2820

页数：5

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