Substituted 4-methylquinolines as a new class of anti-tuberculosis agents

被引：73

作者：

Jain, R ^{[1
]}

Vaitilingam, B ^{[1
]}

Nayyar, A ^{[1
]}

Palde, PB ^{[1
]}

机构：

[1] Natl Inst Pharmaceut Educ & Res, Dept Med Chem, SAS Nagar 160062, Punjab, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 06期

关键词：

D O I：

10.1016/S0960-894X(03)00074-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We report synthesis and anti-tuberculosis activities of a series of novel ring-substituted quinolines. The most effective compound of the series 3d (MIC = 6.25 mug/mL, Mycobacterium tuberculosis H37 Rv strain) was synthesized in one step; thus is an attractive lead molecule for anti-tuberculosis drug development. The results of this study represent the discovery of ring-substituted 4-methylquinolines as new class of potential anti-tuberculosis agents. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：1051 / 1054

页数：4

共 21 条

[1] SILVER(I)-CATALYZED OXIDATIVE DECARBOXYLATION OF ACIDS BY PEROXYDISULFATE - ROLE OF SILVER(II)
ANDERSON, JM
KOCHI, JK
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1970, 92 (06) : 1651 - &
[2] Microplate Alamar blue assay versus BACTEC 460 system for high-throughput screening of compounds against Mycobacterium tuberculosis and Mycobacterium avium
Collins, LA
Franzblau, SG
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (05) : 1004 - 1009
[3] DAVID S, 1996, TUBERCULOSIS
[4] Duncan K, 1997, CHEM IND-LONDON, P861
[5] Rapid, low-technology MIC determination with clinical Mycobacterium tuberculosis isolates by using the microplate Alamar Blue assay
Franzblau, SG
Witzig, RS
McLaughlin, JC
Torres, P
Madico, G
Hernandez, A
Degnan, MT
Cook, MB
Quenzer, VK
Ferguson, RM
Gilman, RH
[J]. JOURNAL OF CLINICAL MICROBIOLOGY, 1998, 36 (02) : 362 - 366
[6] A GENERAL, SELECTIVE, AND CONVENIENT PROCEDURE OF HOMOLYTIC FORMYLATION OF HETEROAROMATIC BASES
GIORDANO, C
MINISCI, F
VISMARA, E
LEVI, S
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1986, 51 (04) : 536 - 537
[7] Synthesis of novel ring-substituted histidines and histamines
Jain, R
Cohen, LA
King, MM
[J]. TETRAHEDRON, 1997, 53 (13) : 4539 - 4548
[8] Regiospecific alkylation of histidine and histamine at C-2
Jain, R
Cohen, LA
ElKadi, NA
King, MM
[J]. TETRAHEDRON, 1997, 53 (07) : 2365 - 2370
[9] KEN D, 1997, J PHARM PHARMACOL, V49, P1
[10] McConnell J, 1998, LANCET, V351, P852

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