Development of chiral catalysts by asymmetric activation for highly enantioselective diethylzinc addition to imines

被引：30

作者：

Zhang, HL

Liu, H

Cui, X

Mi, AQ

Jiang, YZ

Gong, LZ ^{[1
]}

机构：

[1] Chinese Acad Sci, Key Lab Asymmetr Synt & Chirotechnol Sichuan Prov, Chengdu 610041, Peoples R China

[2] Chinese Acad Sci, Union Lab Asymmetr Synth, Chengdu Inst Organ Chem, Chengdu 610041, Peoples R China

[3] Chinese Acad Sci, Grad Sch, Beijing 100864, Peoples R China

来源：

SYNLETT | 2005年 / 04期

关键词：

asymmetric dialkylzinc addition; asymmetric activation; imine;

D O I：

10.1055/s-2005-863709

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Based on the asymmetric activation concept, a library of chiral zinc complexes in situ formed by the combination of diimines derived from chiral 1,2-diphenyl-ethanene-1,2-diamine, BINOL derivatives, and diethylzinc are evaluated in the asymmetric addition of diethylzinc to N-acylimines. In the presence of 10 mol% L3ZnA1, high enantioselectivities and yields were provided for a wide range of aromatic imines in 1,2-dichloroethane at -25 degrees C.

引用

页码：615 / 618

页数：4

共 46 条

[1] Preparation and use of aziridino alcohols as promoters for the enantioselective addition of dialkylzinc reagents to N-(diphenylphosphinoyl) imines [J].