E-cadherin repression contributes to c-Myc-induced epithelial cell transformation

被引：55

作者：

Cowling, V. H.

Cole, M. D.

机构：

[1] Dartmouth Coll Sch Med, Norris Cotton Canc Ctr, Dept Pharmacol, Lebanon, NH 03756 USA

[2] Dartmouth Coll Sch Med, Norris Cotton Canc Ctr, Dept Genet, Lebanon, NH 03756 USA

来源：

ONCOGENE | 2007年 / 26卷 / 24期

基金：

英国医学研究理事会;

关键词：

c-Myc; E-cadherin; transformation; epithelial cell; EMT;

D O I：

10.1038/sj.onc.1210132

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

c-Myc oncoprotein is overexpressed in a significant proportion of human epithelial cancers, and experimental overexpression of c-Myc in epithelial cells promotes tumour formation. However, it is not known how c-Myc promotes epithelial cell tumour formation. We report that c-Myc expression in human mammary epithelial cells induces a dramatic change in cell morphology, with some characteristics of an 'epithelial to mesenchymal transition'. E-cadherin expression is repressed by a post-transcriptional mechanism in cells expressing c-Myc. Furthermore, E-cadherin repression is necessary for c-Myc-induced cell transformation.

引用

收藏

页码：3582 / 3586

页数：5

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