Global phylogeography of Mycobacterium tuberculosis and implications for tuberculosis product development

被引：543

作者：

Gagneux, Sebastien

Small, Peter M.

机构：

[1] Inst Syst Biol, Seattle, WA USA

[2] Bill & Melinda Gates Fdn, Seattle, WA USA

来源：

LANCET INFECTIOUS DISEASES | 2007年 / 7卷 / 05期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S1473-3099(07)70108-1

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

New tools for controlling tuberculosis are urgently needed. Despite our emerging understanding of the biogeography of Mycobacterium tuberculosis, the implications for development of new diagnostics, drugs, and vaccines is unknown. M tuberculosis has a clonal genetic population structure that is geographically constrained. Evidence suggests strain-specific differences in virulence and immunogenicity in light of this global phylogeography. We propose a strain selection framework, based on robust phylogenetic markers, which will allow for systematic and comprehensive evaluation of new tools for tuberculosis control.

引用

收藏

页码：328 / 337

页数：10

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