Enzymatic α(2-3)sialylation of non-natural type-I (Lewisc) disaccharides with recombinant sialyl-transferase

被引:14
作者
Baisch, G [1 ]
Öhrlein, R [1 ]
Streiff, M [1 ]
机构
[1] NOVARTIS PHARMA AG, CH-4002 Basel, Switzerland
关键词
D O I
10.1016/S0960-894X(97)10201-3
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Recombinant alpha(2-3)sialyl-transferase from rat liver is used to sialylate a series of type-I (Lewis(c)) disaccharides on a preparative scale. The enzyme tolerates a broad array of N-acetyl replacements of the N-glucosamine subunit ranging from small and large lipophilic groups to charged and heterocyclic amides. (C) 1998 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:157 / 160
页数:4
相关论文
共 20 条
[1]   Enzymatic galactosylation of non-natural glucosamide-acceptors [J].
Baisch, G ;
Ohrlein, R ;
Ernst, B .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1996, 6 (07) :749-754
[2]   Enzymatic alpha(2-3)-sialylation of non-natural disaccharides with cloned sialyl-transferase [J].
Baisch, G ;
Ohrlein, R ;
Streiff, M ;
Ernst, B .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1996, 6 (07) :755-758
[3]   Enzymatic fucosylation of non-natural trisaccharides with cloned fucosyltransferase VI [J].
Baisch, G ;
Ohrlein, R ;
Katopodis, A ;
Ernst, B .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1996, 6 (07) :759-762
[4]  
BAISCH G, 1997, UNPUB BIOORD MED CHE
[5]   CHEMICALLY SYNTHESIZED OLIGOSACCHARIDES, 1994 - A SEARCHABLE TABLE OF GLYCOSIDIC LINKAGES [J].
BARRESI, F ;
HINDSGAUL, O .
JOURNAL OF CARBOHYDRATE CHEMISTRY, 1995, 14 (08) :1043-1087
[6]   N-ALLYLOXYCARBONYL DERIVATIVES OF D-GLUCOSAMINE AS PROMOTERS OF 1,2-TRANS-GLUCOSYLATION IN KOENIGS-KNORR REACTIONS AND IN LEWIS ACID-CATALYZED CONDENSATIONS [J].
BOULLANGER, P ;
BANOUB, J ;
DESCOTES, G .
CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1987, 65 (06) :1343-1348
[7]  
CRAWLEY SC, 1996, MODERN METHODS CARBO, P492
[8]   Carbohydrate recognition systems: Functional triads in cell-cell interactions [J].
Crocker, PR ;
Feizi, T .
CURRENT OPINION IN STRUCTURAL BIOLOGY, 1996, 6 (05) :679-691
[9]   Glycobiology: Toward understanding the function of sugars [J].
Dwek, RA .
CHEMICAL REVIEWS, 1996, 96 (02) :683-720
[10]   Recent advances in the chemoenzymatic synthesis of carbohydrates and carbohydrate mimetics [J].
Gijsen, HJM ;
Qiao, L ;
Fitz, W ;
Wong, CH .
CHEMICAL REVIEWS, 1996, 96 (01) :443-473