A novel antimicrobial peptide from the sea hare Dolabella auricularia

被引：55

作者：

Iijima, R ^{[1
]}

Kisugi, J ^{[1
]}

Yamazaki, M ^{[1
]}

机构：

[1] Teikyo Univ, Fac Pharmaceut Sci, Sagamiko, Kanagawa 1990195, Japan

来源：

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY | 2003年 / 27卷 / 04期

关键词：

ocean mollusc; Dolabella auricularia; innate immunity; antimicrobial peptide; dolabellanin B2;

D O I：

10.1016/S0145-305X(02)00105-2

中图分类号：

S9 [水产、渔业];

学科分类号：

0908 ;

摘要：

The sea hare Dolabella auricularia is a marine shell-less gastropod. Four cytotoxic glycoproteins named dolabellanin A, C, E and P were found in the animal previously. An antimicrobial factor was newly isolated from the sea hare's body-wall including skin and mucus. This factor is a novel peptide which consists of 33 amino acid residues, and is called dolabellanin B2. Dolabellanin B2 was cytotoxically effective against some pathogenic microorganisms at a concentration of 2.5-100 mug/ml. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：305 / 311

页数：7

共 24 条

[1] ANTIBACTERIAL PEPTIDES - KEY COMPONENTS NEEDED IN IMMUNITY [J].

BOMAN, HG .

CELL, 1991, 65 (02) :205-207

[2] Human beta-defensin-1 is a salt-sensitive antibiotic in lung that is inactivated in cystic fibrosis [J].

Goldman, MJ ;

Anderson, GM ;

Stolzenberg, ED ;

Kari, UP ;

Zasloff, M ;

Wilson, JM .

CELL, 1997, 88 (04) :553-560

[3] Phylogenetic perspectives in innate immunity [J].

Hoffmann, JA ;

Kafatos, FC ;

Janeway, CA ;

Ezekowitz, RAB .

SCIENCE, 1999, 284 (5418) :1313-1318

[4]

IIJIMA R, 1995, DEV COMP IMMUNOL, V19, P13, DOI 10.1016/0145-305X(94)00055-K

[5]

IIJIMA R, 1994, BIOL PHARM BULL, V17, P1144

[6] APLYSIANIN-A, AN ANTIBACTERIAL AND ANTINEOPLASTIC GLYCOPROTEIN IN THE ALBUMIN GLAND OF A SEA HARE, APLYSIA-KURODAI [J].

KAMIYA, H ;

MURAMOTO, K ;

YAMAZAKI, M .

EXPERIENTIA, 1986, 42 (09) :1065-1067

[7] PURIFICATION OF DOLABELLANIN-C AN ANTINEOPLASTIC GLYCOPROTEIN IN THE BODY-FLUID OF A SEA HARE, DOLABELLA-AURICULARIA [J].

KISUGI, J ;

KAMIYA, H ;

YAMAZAKI, M .

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 1989, 13 (01) :3-8

[8]

KISUGI J, 1989, CHEM PHARM BULL, V37, P3050

[9]

KISUGI J, 1992, CHEM PHARM BULL, V40, P1537

[10]

KISUGI J, 1989, CHEM PHARM BULL, V37, P2773

← 1 2 3 →