A novel antimicrobial peptide from the sea hare Dolabella auricularia

被引：55

作者：

Iijima, R ^{[1
]}

Kisugi, J ^{[1
]}

Yamazaki, M ^{[1
]}

机构：

[1] Teikyo Univ, Fac Pharmaceut Sci, Sagamiko, Kanagawa 1990195, Japan

来源：

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY | 2003年 / 27卷 / 04期

关键词：

ocean mollusc; Dolabella auricularia; innate immunity; antimicrobial peptide; dolabellanin B2;

D O I：

10.1016/S0145-305X(02)00105-2

中图分类号：

S9 [水产、渔业];

学科分类号：

0908 ;

摘要：

The sea hare Dolabella auricularia is a marine shell-less gastropod. Four cytotoxic glycoproteins named dolabellanin A, C, E and P were found in the animal previously. An antimicrobial factor was newly isolated from the sea hare's body-wall including skin and mucus. This factor is a novel peptide which consists of 33 amino acid residues, and is called dolabellanin B2. Dolabellanin B2 was cytotoxically effective against some pathogenic microorganisms at a concentration of 2.5-100 mug/ml. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：305 / 311

页数：7

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