Synthesis and properties of chiral peptide nucleic acids with a N-aminoethyl-D-proline backbone

被引：27

作者：

Vilaivan, T

Khongdeesameor, C

Harnyuttanakorn, P

Westwell, MS

Lowe, G

机构：

[1] Univ Oxford, Dyson Perrins Lab, Oxford OX1 3QY, England

[2] Chulalongkorn Univ, Fac Sci, Dept Biol, Bangkok 10330, Thailand

[3] Chulalongkorn Univ, Fac Sci, Dept Chem, Organ Synthesis Res Unit, Bangkok 10330, Thailand

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 22期

关键词：

D O I：

10.1016/S0960-894X(00)00507-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A synthon of D-proline substituted at the 4-position by thymine and at N by a flexible aminoethyl linker, has been used to prepare a novel chiral peptide nucleic acid (cPNA) with (2R,4R) stereochemistry using solid phase methodology. The homo-thymine decamer cPNA binds to complementary polyadenylic acid to form a 2:1 hybrid with high affinity and specificity according to UV and CD studies, whereas no binding to the corresponding polydeoxyadenylic acid was observed. (C) 2000 Published by Elsevier Science Ltd.

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页码：2541 / 2545

页数：5

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