Epidemiological and clinical aspects of hepatitis G virus infection in blood donors and immunocompromised recipients of HGV-contaminated blood

被引:27
作者
Heuft, HG
Berg, T
Schreier, E
Künkel, U
Tacke, M
Schwella, N
Hopf, U
Salama, A
Huhn, D
机构
[1] Humboldt Univ, Klinikum Rudolf Virchow, Abt Innere Med S Hamatol Onkol, D-13353 Berlin, Germany
[2] Humboldt Univ, Blood Bank, D-13353 Berlin, Germany
[3] Robert Koch Inst, D-1000 Berlin, Germany
[4] Boehringer Mannheim GmbH, D-8122 Penzberg, Germany
关键词
D O I
10.1159/000030925
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background and objectives: The infectiousness and clinical relevance of the newly discovered blood-borne Flaviviridae-like agent, termed hepatitis G virus (HGV), are not well understood. Materials and methods: Twenty-three transfusion recipients of two HGV-affected long-term blood donors were studied for HGV genome and antibodies to the putative envelope 2 glycoprotein (anti-E2) of HGV. Nine recipients had nonhematological disorders and 14 suffered from severe hematological diseases and 7 of them received allogeneic bone marrow or blood stem cell transplantation. The molecular epidemiology of the observed HGV infection was studied by direct sequencing of parts of the 5'-noncoding region, NS3, and NS5 region of HGV in the 2 long-term donors and in their 6 recipients who became HGV RNA positive. Additionally, 549 individuals-homologous (n = 254) and autologous blood donors (n = 202), and medical staff (n = 89)-were investigated for the presence of HGV RNA. Results: HGV RNA in serum was found in 15 of the 23 (65%) transfusion recipients with known exposure of HGV-contaminated blood. Seven of the remaining 8 recipients showed only an anti-E2 response, indicating previous HGV infection with spontaneous clearance of the virus. In one recipient neither HGV RNA nor anti-E2 could be detected. Molecular evidence for HGV transmission by the 2 donors was found in 3 of the 6 recipients studied. The alanine aminotransferase levels were not significantly different in the HGV RNA positive and negative recipients, and none of the 23 recipients developed posttransfusion hepatitis. Persistent HGV infection was observed especially in recipients with severe hematological disorders or in those in whom intensive immunosuppressive treatment was necessary. Of the 549 individuals studied, 10 (1.8%) were healthy carriers of HGV RNA. Conclusion: The persistence of transfusion-acquired HGV infection is not associated with acute or chronic hepatitis, but may be influenced by the recipient's underlying disease.
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页码:161 / 167
页数:7
相关论文
共 24 条
[1]   Hepatitis G infection in drug abusers with chronic hepatitis C [J].
Aikawa, T ;
Sugai, Y ;
Okamoto, H .
NEW ENGLAND JOURNAL OF MEDICINE, 1996, 334 (03) :195-196
[2]   The incidence of transfusion-associated hepatitis G virus infection and its relation to liver disease [J].
Alter, HJ ;
Nakatsuji, Y ;
Melpolder, J ;
Wages, J ;
Wesley, R ;
Shih, JWK ;
Kim, JP .
NEW ENGLAND JOURNAL OF MEDICINE, 1997, 336 (11) :747-754
[3]   The cloning and clinical implications of HGV and HGBV-C [J].
Alter, HJ .
NEW ENGLAND JOURNAL OF MEDICINE, 1996, 334 (23) :1536-1537
[4]   Acute non-A-E hepatitis in the United States and the role of hepatitis G virus infection [J].
Alter, MJ ;
Gallagher, M ;
Morris, TT ;
Moyer, LA ;
Meeks, EL ;
Krawczynski, K ;
Kim, JP ;
Margolis, HS .
NEW ENGLAND JOURNAL OF MEDICINE, 1997, 336 (11) :741-746
[5]   Hepatitis-G-virus infection: Epidemiological aspects and clinical relevance [J].
Berg, T ;
Schreier, E ;
Heuft, HG ;
Naumann, U ;
Neuhaus, P ;
Huhn, D ;
Hopf, U .
DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT, 1997, 122 (09) :268-274
[6]   Responsiveness to interferon alpha treatment in patients with chronic hepatitis C coinfected with hepatitis G virus [J].
Berg, T ;
Dirla, U ;
Naumann, U ;
Heuft, HG ;
Kuther, S ;
Lobeck, H ;
Schreier, E ;
Hopf, U .
JOURNAL OF HEPATOLOGY, 1996, 25 (05) :763-768
[7]   GB virus C infection in patients with chronic hepatitis B and C before and after liver transplantation [J].
Berg, T ;
Naumann, U ;
Fukumoto, T ;
Bechstein, WO ;
Neuhaus, P ;
Lobeck, H ;
Hohne, M ;
Schreier, E ;
Hopf, U .
TRANSPLANTATION, 1996, 62 (06) :711-714
[8]   High prevalence of GB virus C infection in a group of Italian patients with hepatitis of unknown etiology [J].
Fiordalisi, G ;
Zanella, I ;
Mantero, G ;
Bettinardi, A ;
Stellini, R ;
Paraninfo, G ;
Cadeo, G ;
Primi, D .
JOURNAL OF INFECTIOUS DISEASES, 1996, 174 (01) :181-183
[9]   Clinical presentation of GB-C virus infection in drug abusers with chronic hepatitis C [J].
Goeser, T ;
Seipp, S ;
Wahl, R ;
Muller, HM ;
Stremmel, W ;
Theilmann, L .
JOURNAL OF HEPATOLOGY, 1997, 26 (03) :498-502
[10]   Association between fulminant hepatic failure and a strain of GBV virus C [J].
Heringlake, S ;
Osterkamp, S ;
Trautwein, C ;
Tillmann, HL ;
Boker, K ;
Muerhoff, S ;
Mushahwar, IK ;
Hunsmann, G ;
Manns, MP .
LANCET, 1996, 348 (9042) :1626-1629