An autonomous polymerization motor powered by DNA hybridization

被引：275

作者：

Venkataraman, Suvir

Dirks, Robert M.

Rothemund, Paul W. K.

Winfree, Erik

Pierce, Niles A. ^{[1
]}

机构：

[1] CALTECH, Dept Bioengn, Pasadena, CA 91125 USA

[2] CALTECH, Dept Comp Sci, Pasadena, CA 91125 USA

[3] CALTECH, Dept Comp & Neural Syst, Pasadena, CA 91125 USA

[4] CALTECH, Dept Appl & Computat Math, Pasadena, CA 91125 USA

来源：

NATURE NANOTECHNOLOGY | 2007年 / 2卷 / 08期

关键词：

D O I：

10.1038/nnano.2007.225

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

We present a synthetic molecular motor capable of autonomous nanoscale transport in solution. Inspired by bacterial pathogens such as Rickettsia rickettsii, which locomote by inducing the polymerization of the protein actin at their surfaces to form 'comet tails' 1, the motor operates by polymerizing a double-helical DNA tail(2). DNA strands are propelled processively at the living end of the growing polymers, demonstrating autonomous locomotion powered by the free energy of DNA hybridization.

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页码：490 / 494

页数：5

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