Interfering with leukocyte rolling -: a promising therapeutic approach in inflammatory skin disorders?

被引：28

作者：

Boehncke, WH

Schön, MP

机构：

[1] Goethe Univ Frankfurt, Dept Dermatol & Venerol, D-60590 Frankfurt, Germany

[2] Otto Von Guericke Univ, Dept Dermatol & Venerol, D-39120 Magdeburg, Germany

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2003年 / 24卷 / 02期

关键词：

D O I：

10.1016/S0165-6147(02)00039-1

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

Many novel anti-inflammatory compounds have been derived from research tools designed to better understand the complex process of leukocyte extravasation at sites of inflammation. Given that selectin-mediated rolling is the crucial initial step of leukocyte localization to the skin, specific interference with this mechanism is a particularly attractive target to treat cutaneous inflammation. Recently, several exciting advances have been reported aimed at selective interference with specific target molecules crucially involved in leukocyte rolling.

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页码：49 / 52

页数：4

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