A crack in histone lysine methylation

被引：123

作者：

Kubicek, S ^{[1
]}

Jenuwein, T ^{[1
]}

机构：

[1] Vienna Bioctr, Res Inst Mol Pathol, A-1030 Vienna, Austria

来源：

CELL | 2004年 / 119卷 / 07期

关键词：

D O I：

10.1016/j.cell.2004.12.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Histone lysine methylation is regarded as a very stable modification with important functions in epigenetic gene control and for organizing chromatin domains. While more robust modifications of the chromatin template are essential to stabilize epigenetic information, there is now the first evidence for a histone lysine demethylase that reverts an activating methyl mark to the unmodified state (Shi et al., 2004 [this issue of Ceff]).

引用

页码：903 / 906

页数：4

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