Evolution and functional classification of vertebrate gene deserts

被引：181

作者：

Ovcharenko, I ^{[1
]}

Loots, GG

Nobrega, MA

Hardison, RC

Miller, W

Stubbs, L

机构：

[1] Lawrence Livermore Natl Lab, Energy Environm Biol & Inst Comp, Livermore, CA 94550 USA

[2] Lawrence Livermore Natl Lab, Genome Biol Div, Livermore, CA 94550 USA

[3] Univ Calif Berkeley, Lawrence Berkeley Lab, Genom Div, Berkeley, CA 94720 USA

[4] Penn State Univ, Dept Biochem & Mol Biol, University Pk, PA 16802 USA

[5] Penn State Univ, Dept Comp Sci & Engn, University Pk, PA 16802 USA

[6] Penn State Univ, Dept Biol, University Pk, PA 16802 USA

来源：

GENOME RESEARCH | 2005年 / 15卷 / 01期

关键词：

D O I：

10.1101/gr.3015505

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Large tracts of the human genome, known as gene deserts, are devoid of protein-coding genes. Dichotomy in their level of conservation with chicken separates these regions into two distinct categories, stable and variable. The separation is not caused by differences in rates of neutral evolution but instead appears to be related to different biological functions of stable and variable gene deserts in the human genome. Gene Ontology categories of the adjacent genes are strongly biased toward transcriptional regulation and development for the stable gene deserts, and toward distinctively different functions for the variable gene deserts. Stable gene deserts resist chromosomal rearrangements and appear to harbor multiple distant regulatory elements physically linked to their neighboring genes, with the linearity of conservation invariant throughout vertebrate evolution.

引用

页码：137 / 145

页数：9

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