Increased blood flow by insulin infusion targeting normoglycemia in patients with severe sepsis: friend or foe?

被引：2

作者：

Van den Berghe, Greet ^{[1
]}

机构：

[1] Catholic Univ Louvain, Dept Intens Care Med, B-3000 Louvain, Belgium

来源：

CRITICAL CARE | 2010年 / 14卷 / 01期

关键词：

CRITICALLY-ILL PATIENTS; INTENSIVE INSULIN; THERAPY; HYPERINSULINEMIA; INFLAMMATION;

D O I：

10.1186/cc8228

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

A small study in patients with severe sepsis suggested that insulin infused to normalize blood glucose levels increased forearm flow. This clinical observation supports the effect of insulin on the endothelium, as previously shown by in vitro studies and by in vivo animal models of critical illness, but the clinical consequences remain unclear.

引用

页数：2

共 11 条

[1] Hyperglycemia prevents the suppressive effect of hyperinsulinemia on plasma adiponectin levels in healthy humans [J].

Blumer, Regje M. E. ;

van der Crabben, Saskia N. ;

Stegenga, Michiel E. ;

Tanck, Michael W. ;

Ackermans, Mariette T. ;

Endert, Erik ;

van der Poll, Tom ;

Sauerwein, Hans P. .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2008, 295 (03) :E613-E617

[2] Insulin suppresses plasma concentration of vascular endothelial growth factor and matrix metalloproteinase-9 [J].

Dandona, P ;

Aljada, A ;

Mohanty, P ;

Ghanim, H ;

Bandyopadhyay, A ;

Chaudhuri, A .

DIABETES CARE, 2003, 26 (12) :3310-3314

[3] Endothelial dysfunction, inflammation and diabetes [J].

Dandona, P ;

Aljada, A ;

Chaudhuri, A ;

Mohanty, P .

REVIEWS IN ENDOCRINE & METABOLIC DISORDERS, 2004, 5 (03) :189-197

[4] The potential influence of inflammation and insulin resistance on the pathogenesis and treatment of atherosclerosis-related complications in type 2 diabetes [J].

Dandona, P ;

Aljada, A ;

Chaudhuri, A ;

Bandyopadhyay, A .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2003, 88 (06) :2422-2429

[5] Survival benefits of intensive insulin therapy in critical illness - Impact of maintaining normoglycemia versus glycemia-independent actions of insulin [J].

Ellger, B ;

Debaveye, Y ;

Vanhorebeek, I ;

Langouche, L ;

Giulietti, A ;

Van Etten, E ;

Herijgers, P ;

Mathieu, C ;

Van den Berghe, G .

DIABETES, 2006, 55 (04) :1096-1105

[6] Intensive insulin therapy protects the endothelium of critically ill patients [J].

Langouche, L ;

Vanhorebeek, I ;

Vlasselaers, D ;

Vander Perre, S ;

Wouters, PJ ;

Skogstrand, K ;

Hansen, TK ;

Van den Berghe, G .

JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (08) :2277-2286

[7] Hyperglycemia enhances coagulation and reduces neutrophil degranulation, whereas hyperinsulinemia, inhibits fibrinolysis during human endotoxemia [J].

Stegenga, Michiel E. ;

van der Crabben, Saskia N. ;

Bluemer, Regje M. E. ;

Levi, Marcel ;

Meijers, Joost C. M. ;

Serlie, Mireille J. ;

Tanck, Michael W. T. ;

Sauerwein, Hans P. ;

van der Poll, Tom .

BLOOD, 2008, 112 (01) :82-89

[8] Acute hyperglycemia exacerbates myocardial ischemia/reperfusion injury and blunts cardioprotective effect of GIK [J].

Su, Hui ;

Sun, Xin ;

Ma, Heng ;

Zhang, Hai-Feng ;

Yu, Qiu-Jun ;

Huang, Chen ;

Wang, Xiao-Ming ;

Luan, Rong-Hua ;

Jia, Guo-Liang ;

Wang, Hai-Chang ;

Gao, Feng .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2007, 293 (03) :E629-E635

[9] Intensive insulin therapy in critically ill patients. [J].

Van den Berghe, G ;

Wouters, P ;

Weekers, F ;

Verwaest, C ;

Bruyninckx, F ;

Schetz, M ;

Vlasselaers, D ;

Ferdinande, P ;

Lauwers, P ;

Bouillon, R .

NEW ENGLAND JOURNAL OF MEDICINE, 2001, 345 (19) :1359-1367

[10] Intensive Insulin Therapy in Critically Ill Patients: NICE-SUGAR or Leuven Blood Glucose Target? [J].

Van den Berghe, Greet ;

Schetz, Miet ;

Vlasselaers, Dirk ;

Hermans, Greet ;

Wilmer, Alexander ;

Bouillon, Roger ;

Mesotten, Dieter .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2009, 94 (09) :3163-3170

← 1 2 →