Concise Review: Multiple Niches for Hematopoietic Stem Cell Regulations

被引：62

作者：

Oh, Il-Hoan ^{[1
]}

Kwon, Kyung-Rim ^{[1
]}

机构：

[1] Catholic Univ Korea, Catholic High Performance Cell Therapy Ctr, Div Regenerat Med, Coll Med, Seoul 137701, South Korea

来源：

STEM CELLS | 2010年 / 28卷 / 07期

关键词：

Stem cell niche; Microenvironment; Osteoblast; Vascular niche; SELF-RENEWAL; STEM/PROGENITOR CELLS; PROGENITOR CELLS; IN-VITRO; MARROW; RECONSTITUTION; MAINTENANCE; MICROENVIRONMENT; MOBILIZATION; MICE;

D O I：

10.1002/stem.453

中图分类号：

Q813 [细胞工程];

学科分类号：

100113 [医学细胞生物学];

摘要：

Two types of stern cell niches in bone marrow (BM), endosteal osteoblastic, and vascular niches are involved in the microenvironmental regulation of hematopoietic stem cells (HSCs). Recently, redundant features of the two niches were identified, based on their common cellular origins or chemical mediators being produced in each niche. In contrast, studies have also revealed that HSCs are localized differentially in the niches with respect to their distinct functional status, and that the biological activity of each niche is differentially influenced by extrinsic conditions. An important question is, therefore, whether these two niches play distinct roles in regulating HSCs and whether they respond differentially to environmental stimuli/stress for "compartmentalized" niche organization in BM. In this review, recent discoveries related to the characteristics of each type of niche and their common or unique features are discussed, along with the possibility of multiniche regulation of HSCs in BM. STEM CELLS 2010:28:1243-1249

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页码：1243 / 1249

页数：7

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