Polyprenylated benzophenones from Garcinia assigu and their potential cancer chemopreventive activities

被引：90

作者：

Ito, C

Itoigawa, M ^{[1
]}

Miyamoto, Y

Onoda, S

Rao, KS

Mukainaka, T

Tokuda, H

Nishino, H

Furukawa, H

机构：

[1] Tokai Gakuen Univ, Miyoshi, Aichi 4700207, Japan

[2] Meijo Univ, Fac Pharm, Tempaku Ku, Nagoya, Aichi 4688503, Japan

[3] Univ Papua New Guinea, Dept Chem, Port Moresby, Papua N Guinea

[4] Kyoto Prefectural Univ Med, Dept Biochem, Kamigyo Ku, Kyoto 6020841, Japan

来源：

JOURNAL OF NATURAL PRODUCTS | 2003年 / 66卷 / 02期

关键词：

D O I：

10.1021/np020372g

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

In a further study on the chemical constituents of Garcinia assigu, two new benzophenones corresponding to the 13-O-methyl ethers (I and 2) of the known isogarcinol and garcinol, respectively, were isolated and characterized, along with known benzophenones (3-6). Inhibitory effects of the benzophenones isolated from this plant on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetrade-canoylphorbol-13-acetate (TPA) in Raji cells and their radical-scavenging ability against 1,1-diphenyl-2-picrylhydrazyl (DPPH) were demonstrated. The cyclized polyprenylbenzophenones (1-5) showed comparable or stronger potential cancer chemopreventive activity when compared to glycyrrhetic acid, a known anti-tumor promoter.

引用

页码：206 / 209

页数：4

共 15 条

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