Facile construction and divergent transformation of polycyclic isoxazoles: Direct access to polyketide architectures

被引：52

作者：

Bode, JW

Hachisu, Y

Matsuura, T

Suzuki, K ^{[1
]}

机构：

[1] Tokyo Inst Technol, Dept Chem, Meguro Ku, Tokyo 1528551, Japan

[2] Japan Sci & Technol Corp, CREST, Meguro Ku, Tokyo 1528551, Japan

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 04期

关键词：

D O I：

10.1021/ol027283f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Base-promoted cyclocondensation of C-chloro oximes with cyclic 1,3-diketones affords functionalized isoxazoles in good yield and under convenient reaction conditions. This process enables the synthesis of highly substituted products with notable functional group tolerance. The products obtained are directly converted to a variety of polyketide-derived polycyclic structures including xanthenes, anthracenes, and benzophenones.

引用

页码：391 / 394

页数：4

共 11 条

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