The human FXY gene is located within Xp22.3: implications for evolution of the mammalian X chromosome

被引：19

作者：

Perry, J

Feather, S

Smith, A

Palmer, S

Ashworth, A

机构：

[1] Inst Canc Res, Chester Beatty Labs, CRC, Ctr Cell & Mol Biol, London SW3 6JB, England

[2] Inst Canc Res, Chester Beatty Labs, Sect Gene Funct & Regulat, London SW3 6JB, England

[3] Inst Child Hlth, Mol Genet Unit, London WC1 1EH, England

来源：

HUMAN MOLECULAR GENETICS | 1998年 / 7卷 / 02期

关键词：

D O I：

10.1093/hmg/7.2.299

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It has been proposed that the pseudoautosomal region of mammals has evolved by sequential addition of autosomal material onto the X and Y chromosomes followed by movement of the pseudoautosomal boundary to create X-unique regions, We have previously described a gene, Fxy,that spans the pseudoautosomal boundary in mice such that the first three exons of the gene are located on the X chromosome, but the remainder of the gene is located on both X and Y chromosomes, Therefore, this gene might be in a state of transition between pseudoautosomal and X-unique locations, In support of this theory we show here that the human FXY gene is located in Xp22.3 in humans, proximal to the pseudoautosomal boundary.

引用

页码：299 / 305

页数：7

共 38 条

[1] A YEAST ARTIFICIAL CHROMOSOME CONTIG ENCOMPASSING THE CYSTIC-FIBROSIS LOCUS [J].