Evolutionary formation of new centromeres in macaque

被引：116

作者：

Ventura, Mario

Antonacci, Francesca

Cardone, Maria Francesca

Stanyon, Roscoe

D'Addabbo, Pietro

Cellamare, Angelo

Sprague, L. James

Eichler, Evan E.

Archidiacono, Nicoletta

Rocchi, Mariano ^{[1
]}

机构：

[1] Univ Bari, Dept Genet & Microbiol, I-70126 Bari, Italy

[2] Univ Florence, Dept Anim Biol & Genet, I-50125 Florence, Italy

[3] Univ Washington, Sch Med, Howard Hughes Med Inst, Dept Genome Sci, Seattle, WA 98195 USA

来源：

SCIENCE | 2007年 / 316卷 / 5822期

关键词：

D O I：

10.1126/science.1140615

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A systematic fluorescence in situ hybridization comparison of macaque and human synteny organization disclosed five additional macaque evolutionary new centromeres ( ENCs) for a total of nine ENCs. To understand the dynamics of ENC formation and progression, we compared the ENC of macaque chromosome 4 with the human orthologous region, at 6q24.3, that conserves the ancestral genomic organization. A 250-kilobase segment was extensively duplicated around the macaque centromere. These duplications were strictly intrachromosomal. Our results suggest that novel centromeres may trigger only local duplication activity and that the absence of genes in the seeding region may have been important in ENC maintenance and progression.

引用

页码：243 / 246

页数：4

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