Structure and function in the nucleus

被引：773

作者：

Lamond, AI ^{[1
]}

Earnshaw, WC

机构：

[1] Univ Dundee, Dept Biochem, Dundee DD1 4HN, Scotland

[2] Univ Edinburgh, Inst Cell & Mol Biol, Edinburgh EH9 3JR, Midlothian, Scotland

来源：

SCIENCE | 1998年 / 280卷 / 5363期

基金：

英国惠康基金;

关键词：

D O I：

10.1126/science.280.5363.547

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Current evidence suggests that the nucleus has a distinct substructure, albeit one that is dynamic rather than a rigid framework. Viral infection, oncogene expression, and inherited human disorders can each cause profound and specific changes in nuclear organization. This review summarizes recent progress in understanding nuclear organization, highlighting in particular the dynamic aspects of nuclear structure.

引用

页码：547 / 553

页数：7

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