学术探索
学术期刊
新闻热点
数据分析
智能评审

Structure and function in the nucleus

被引：773
作者：
Lamond, AI [1 ]
Earnshaw, WC
机构：
[1] Univ Dundee, Dept Biochem, Dundee DD1 4HN, Scotland
[2] Univ Edinburgh, Inst Cell & Mol Biol, Edinburgh EH9 3JR, Midlothian, Scotland
来源：
SCIENCE | 1998年 / 280卷 / 5363期
基金：
英国惠康基金;
关键词：
D O I：
10.1126/science.280.5363.547
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Current evidence suggests that the nucleus has a distinct substructure, albeit one that is dynamic rather than a rigid framework. Viral infection, oncogene expression, and inherited human disorders can each cause profound and specific changes in nuclear organization. This review summarizes recent progress in understanding nuclear organization, highlighting in particular the dynamic aspects of nuclear structure.
引用
收藏
页码：547 / 553
页数：7
相关论文
共 178 条
  • [81] Lamond Angus I., 1993, Trends in Cell Biology, V3, P198, DOI 10.1016/0962-8924(93)90214-L
  • [82] SUBNUCLEAR LOCALIZATION OF WT1 IN SPLICING OR TRANSCRIPTION FACTOR DOMAINS IS REGULATED BY ALTERNATIVE SPLICING
    LARSSON, SH
    CHARLIEU, JP
    MIYAGAWA, K
    ENGELKAMP, D
    RASSOULZADEGAN, M
    ROSS, A
    CUZIN, F
    VANHEYNINGEN, V
    HASTIE, ND
    [J]. CELL, 1995, 81 (03) : 391 - 401
  • [83] LAVAU C, 1995, ONCOGENE, V11, P871
  • [84] A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors
    LeDouarin, B
    Nielsen, AL
    Garnier, JM
    Ichinose, H
    Jeanmougin, F
    Losson, R
    Chambon, P
    [J]. EMBO JOURNAL, 1996, 15 (23) : 6701 - 6715
  • [85] IDENTIFICATION AND CHARACTERIZATION OF A SPINAL MUSCULAR ATROPHY-DETERMINING GENE
    LEFEBVRE, S
    BURGLEN, L
    REBOULLET, S
    CLERMONT, O
    BURLET, P
    VIOLLET, L
    BENICHOU, B
    CRUAUD, C
    MILLASSEAU, P
    ZEVIANI, M
    LEPASLIER, D
    FREZAL, J
    COHEN, D
    WEISSENBACH, J
    MUNNICH, A
    MELKI, J
    [J]. CELL, 1995, 80 (01) : 155 - 165
  • [86] SPLICING PRECEDES POLYADENYLATION DURING DROSOPHILA E74A TRANSCRIPTION
    LEMAIRE, MF
    THUMMEL, CS
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 1990, 10 (11) : 6059 - 6063
  • [87] LESER GP, 1989, EUR J CELL BIOL, V50, P376
  • [88] Interphase cell cycle dynamics of a late-replicating, heterochromatic homogeneously staining region: Precise choreography of condensation/decondensation and nuclear positioning
    Li, G
    Sudlow, G
    Belmont, AS
    [J]. JOURNAL OF CELL BIOLOGY, 1998, 140 (05) : 975 - 989
  • [89] DELINEATION OF INDIVIDUAL HUMAN-CHROMOSOMES IN METAPHASE AND INTERPHASE CELLS BY INSITU SUPPRESSION HYBRIDIZATION USING RECOMBINANT DNA LIBRARIES
    LICHTER, P
    CREMER, T
    BORDEN, J
    MANUELIDIS, L
    WARD, DC
    [J]. HUMAN GENETICS, 1988, 80 (03) : 224 - 234
  • [90] The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins
    Liu, Q
    Fischer, U
    Wang, F
    Dreyfuss, G
    [J]. CELL, 1997, 90 (06) : 1013 - 1021
45678910111213