Steroidal Saponins from Two Species of Dracaena

被引：40

作者：

Kougan, Guy Beddos ^{[1
,2
]}

Miyamoto, Tomofumi ^{[3
]}

Tanaka, Chiaki ^{[3
]}

Paululat, Thomas ^{[4
]}

Mirjolet, Jean-Francois

Duchamp, Olivier

Sondengam, Beibam Lucas ^{[2
]}

Lacaille-Dubois, Marie-Aleth ^{[1
]}

机构：

[1] Univ Bourgogne, Fac Pharm, UMIB UPRES EA 3660, Unite Mol Interet Biol,Lab Pharmacognosie, F-21079 Dijon, France

[2] Univ Yaounde 1, Fac Sci, Dept Chim Organ, Lab Chim Subst Nat, Yaounde, Cameroon

[3] Kyushu Univ, Grad Sch Pharmaceut Sci, Fukuoka 8128582, Japan

[4] Univ Siegen, D-57068 Siegen, Germany

来源：

JOURNAL OF NATURAL PRODUCTS | 2010年 / 73卷 / 07期

关键词：

ORIENTALIS; BLOOD; STEMS;

D O I：

10.1021/np100153m

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Four new steroidal saponins (1-4) were isolated from the stem and bark of two species of Dracaena: deistelianosides A and B (1 and 2) from D. deisteliana and arboreasaponins A and B (3 and 4) front D. arborea. Six known saponins and one known sapogenin were also isolated. The structures of 1-4 were established as diosgenin 3-O-[3-O-sulfate-alpha-L-rhamnopyranosyl-(1 -> 4)]-beta-D-glueopyranoside (1), 1-O-beta-D-xylopyranosyl-(1 -> 2)-[alpha-L-rhamnopyranosyl-(1 -> 3)]-beta-D-fucopyranosyl(23S,24S)-spirosta-5,25(27)-diene-1 beta,3 beta,23 alpha,24 alpha-tetrol 24-O-alpha-L-arabinopyranoside (2), pennogenin-3-O-alpha-L-rhamnopyranosyl-(1 -> 2)-[alpha-L-rhamnopyranosyl-(1 -> 3)]-[6-O-acetyl]-beta-D-glucopyranoside (3), and 24 alpha-hydroxypennogenin 3-O-alpha-L-rhamnopyranosyl-(1 -> 2)-[alpha-L-rhamnopyranosyl-(1 -> 3)]-beta-D-glucopyranoside (4) using extensive 1D and 2D NMR spectroscopic analyses and mass spectrometry. Cytotoxic activity of several of these compounds was evaluated against the HT-29 and HCT 116 human colon cancer cell lines.

引用

页码：1266 / 1270

页数：5

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