Junctional complexes of the blood-brain barrier: permeability changes in neuroinflammation

被引：266

作者：

Petty, MA

Lo, EH

机构：

[1] Aventis Pharmaceut Inc, CNS Pharmacol, Bridgewater, NJ 08807 USA

[2] Massachusetts Gen Hosp, Dept Neurol, Neuroprotect Res Lab, Boston, MA 02114 USA

[3] Massachusetts Gen Hosp, Dept Radiol, Boston, MA 02114 USA

[4] Harvard Univ, Sch Med, Program Neurosci, Harvard, MA USA

来源：

PROGRESS IN NEUROBIOLOGY | 2002年 / 68卷 / 05期

关键词：

D O I：

10.1016/S0301-0082(02)00128-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A wide range of central nervous system (CNS) disorders include neuroinflammatory events that perturb blood-brain barrier (BBB) integrity. Mechanisms by which the BBB responds to physiological and pathological stimuli involve signaling systems in the tight and adherens junctions of the cerebral endothelium. In this review, we examine the molecular composition and regulatory mediators that control BBB permeability and assess how these mediators may be dysregulated in stroke, multiple sclerosis, brain tumors, and meningioencephalitis. An understanding of these molecular substrates in BBB regulation may lead to new approaches for enhancing CNS drug delivery and ameliorating brain edema after injury and inflammation. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：311 / 323

页数：13

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