Junctional complexes of the blood-brain barrier: permeability changes in neuroinflammation

被引：266

作者：

Petty, MA

Lo, EH

机构：

[1] Aventis Pharmaceut Inc, CNS Pharmacol, Bridgewater, NJ 08807 USA

[2] Massachusetts Gen Hosp, Dept Neurol, Neuroprotect Res Lab, Boston, MA 02114 USA

[3] Massachusetts Gen Hosp, Dept Radiol, Boston, MA 02114 USA

[4] Harvard Univ, Sch Med, Program Neurosci, Harvard, MA USA

来源：

PROGRESS IN NEUROBIOLOGY | 2002年 / 68卷 / 05期

关键词：

D O I：

10.1016/S0301-0082(02)00128-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A wide range of central nervous system (CNS) disorders include neuroinflammatory events that perturb blood-brain barrier (BBB) integrity. Mechanisms by which the BBB responds to physiological and pathological stimuli involve signaling systems in the tight and adherens junctions of the cerebral endothelium. In this review, we examine the molecular composition and regulatory mediators that control BBB permeability and assess how these mediators may be dysregulated in stroke, multiple sclerosis, brain tumors, and meningioencephalitis. An understanding of these molecular substrates in BBB regulation may lead to new approaches for enhancing CNS drug delivery and ameliorating brain edema after injury and inflammation. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：311 / 323

页数：13

相关论文

共 145 条

[61] Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2 and ZO-3, with the COOH termini of claudins [J].

Itoh, M ;

Furuse, M ;

Morita, K ;

Kubota, K ;

Saitou, M ;

Tsukita, S .

JOURNAL OF CELL BIOLOGY, 1999, 147 (06) :1351-1363

[62] An atypical PKC directly associates and colocalizes at the epithelial tight junction with ASIP, a mammalian homologue of Caenorhabditis elegans polarity protein PAR-3 [J].

Izumi, Y ;

Hirose, T ;

Tamai, Y ;

Hirai, S ;

Nagashima, Y ;

Fujimoto, T ;

Tabuse, Y ;

Kemphues, KJ ;

Ohno, S .

JOURNAL OF CELL BIOLOGY, 1998, 143 (01) :95-106

[63] Vascular cell adhesion molecule-1 mRNA is expressed in immune-mediated and ischemic injury of the rat nervous system [J].

Jander, S ;

Pohl, J ;

Gillen, C ;

Schroeter, M ;

Stoll, G .

JOURNAL OF NEUROIMMUNOLOGY, 1996, 70 (01) :75-80

[64] Matrix metalloproteinase-9 and -7 are regulated in experimental autoimmune encephalomyelitis [J].

Kieseier, BC ;

Kiefer, R ;

Clements, JM ;

Miller, K ;

Wells, GMA ;

Schweitzer, T ;

Gearing, AJH ;

Hartung, HP .

BRAIN, 1998, 121 :159-166

[65] NEUROVASCULAR PERMEABILITY AND FIBRIN DEPOSITION IN THE CENTRAL NEURAXIS OF LEWIS RATS WITH CELL-TRANSFERRED EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS IN RELATIONSHIP TO CLINICAL AND HISTOPATHOLOGICAL FEATURES OF THE DISEASE [J].

KOH, CS ;

GAUSAS, J ;

PATERSON, PY .

JOURNAL OF NEUROIMMUNOLOGY, 1993, 47 (02) :141-145

[66]

KOH CS, 1992, J NEUROIMMUNOL, V38, P85

[67] Matrix metalloproteinases and tissue inhibitors of metalloproteinases in viral meningitis: upregulation of MMP-9 and TIMP-1 in cerebrospinal fluid [J].

Kolb, SA ;

Lahrtz, F ;

Paul, R ;

Leppert, D ;

Nadal, D ;

Pfister, HW ;

Fontana, A .

JOURNAL OF NEUROIMMUNOLOGY, 1998, 84 (02) :143-150

[68] Astroglial cells inhibit the increasing permeability of brain endothelial cell monolayer following hypoxia reoxygenation [J].

Kondo, T ;

Kinouchi, H ;

Kawase, M ;

Yoshimoto, T .

NEUROSCIENCE LETTERS, 1996, 208 (02) :101-104

[69] Regulation of the MDCK cell tight junction [J].

Kovbasnjuk, ON ;

Szmulowicz, U ;

Spring, KR .

JOURNAL OF MEMBRANE BIOLOGY, 1998, 161 (01) :93-104

[70] Outwitting the blood-brain barrier for therapeutic purposes: Osmotic opening and other means [J].

Kroll, RA ;

Neuwelt, EA .

NEUROSURGERY, 1998, 42 (05) :1083-1099

← 2 3 4 5 6 7 8 9 10 11 →