In vitro antileishmanial activity of nicotinamide

被引：50

作者：

Sereno, D ^{[1
]}

Alegre, AM

Silvestre, R

Vergnes, B

Ouaissi, A

机构：

[1] Ctr IRD Montpellier, U R008, Montpellier, France

[2] Univ Porto, Fac Pharm, Dept Biochem, P-4100 Oporto, Portugal

[3] Univ Porto, Inst Mol & Cellular Biol, P-4100 Oporto, Portugal

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2005年 / 49卷 / 02期

关键词：

D O I：

10.1128/AAC.49.2.808-812.2005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Our study represents the first report demonstrating the antileishmanial activity of nicotinamide (NAm), a form of vitamin B-3. A 5 mM concentration of NAm significantly inhibited the intracellular growth of Leishmania amastigotes and the NAD-dependent deacetylase activity carried by parasites overexpressing Leishmania major SIR2 (LmSIR2). However, the transgenic parasites were as susceptible as the wild-type parasites to NAm-induced cell growth arrest. Therefore, we conclude that NAm inhibits leishmanial growth and that overexpression of LmSIR2 does not overcome this inhibition. The mechanism of the inhibition is not defined but may include other in vivo targets. NAm may thus represent a new antileishmanial agent which could potentially be used in combination with other drugs during therapy.

引用

页码：808 / 812

页数：5

共 16 条

[1] Pharmacokinetics of nicotinamide in cancer patients treated with accelerated radiotherapy:: the experience of the Co-operative Group of Radiotherapy of the European Organization for Research and Treatment of Cancer [J].