Micellar nanocontainers distribute to defined cytoplasmic organelles

被引：969

作者：

Savic, R

Luo, LB

Eisenberg, A

Maysinger, D

机构：

[1] McGill Univ, Dept Pharmacol & Therapeut, Montreal, PQ H3G 1Y6, Canada

[2] McGill Univ, Dept Chem, Montreal, PQ H3A 2K6, Canada

来源：

SCIENCE | 2003年 / 300卷 / 5619期

关键词：

D O I：

10.1126/science.1078192

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Block copolymer micelles are water-soluble biocompatible nanocontainers with great potential for delivering hydrophobic drugs. An understanding of their cellular distribution is essential to achieving selective delivery of drugs at the subcellular level. Triple-labeling confocal microscopy in live cells revealed the localization of micelles in several cytoplasmic organelles, including mitochondria, but not in the nucleus. Moreover, micelles change the cellular distribution of and increase the amount of the agent delivered to the cells. These micelles may thus be worth exploring for their potential to selectively deliver drugs to specified subcellular targets.

引用

页码：615 / 618

页数：4

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