Molecular cloning of a novel human receptor gene with homology to the rat adrenomedullin receptor and high expression in heart and immune system

被引:41
作者
Hanze, J
Dittrich, K
Dotsch, J
Rascher, W
机构
[1] Department of Pediatrics, University of Giessen, D-35385, Giessen
关键词
D O I
10.1006/bbrc.1997.7631
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A novel human gene (named hrhAMR) encoding a seven transmembrane receptor which shares a homology of 73% on the amino acid level with the rat adrenomedullin (AM) receptor has been isolated by a polymerase-chain-reaction (PCR) cloning strategy. Southern- and Northern-blot analysis suggest a single hrhAMR gene, which is highly expressed in heart, skeletal muscle, immune system, adrenal gland and liver, an expression pattern being quite different to that found in rat tissues with the homologue rat probe. Because of its homology with the rat AM receptor, we speculate that potential ligands may be members of the calcitonin-gene-related-peptide/amylin/adrenomedullin peptide family. (C) 1997 Academic Press.
引用
收藏
页码:183 / 188
页数:6
相关论文
共 23 条
[21]   ENDOTHELIAL-CELLS ACTIVELY SYNTHESIZE AND SECRETE ADRENOMEDULLIN [J].
SUGO, S ;
MINAMINO, N ;
KANGAWA, K ;
MIYAMOTO, K ;
KITAMURA, K ;
SAKATA, J ;
ETO, T ;
MATSUO, H .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1994, 201 (03) :1160-1166
[22]   Adrenomedullin-immunoreactive neurons in the paraventricular and supraoptic nuclei of the rat [J].
Ueta, Y ;
Kitamura, K ;
Isse, T ;
Shibuya, I ;
Kabashima, N ;
Yamamoto, S ;
Kangawa, K ;
Matsuo, H ;
Eto, T ;
Yamashita, H .
NEUROSCIENCE LETTERS, 1995, 202 (1-2) :37-40
[23]   ADRENOMEDULLIN AND CALCITONIN-GENE-RELATED PEPTIDE INTERACT WITH THE SAME RECEPTOR IN CULTURED HUMAN NEUROBLASTOMA SK-N-MC CELLS [J].
ZIMMERMANN, U ;
FISCHER, JA ;
MUFF, R .
PEPTIDES, 1995, 16 (03) :421-424