Induction of mexCD-oprJ operon for a multidrug efflux pump by disinfectants in wild-type Pseudomonas aeruginosa PAO1

被引：88

作者：

Morita, Y

Murata, T

Mima, T

Shiota, S

Kuroda, T

Mizushima, T

Gotoh, N

Nishino, T

Tsuchiya, T ^{[1
]}

机构：

[1] Okayama Univ, Fac Pharmaceut Sci, Dept Microbiol, Okayama 7008530, Japan

[2] Kyoto Pharmaceut Univ, Dept Microbiol, Kyoto 6078414, Japan

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 2003年 / 51卷 / 04期

关键词：

MexCD-OprJ; multidrug efflux pump; inducers; P; aeruginosa;

D O I：

10.1093/jac/dkg173

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Induction of the MexCD-OprJ multidrug efflux pump was investigated in wild-type Pseudomonas aeruginosa PAO1 - MexCD-OprJ was induced by clinically important disinfectants such as benzalkonium chloride and chlorhexidine gluconate, and by some cytotoxic agents such as tetraphenylphosphonium chloride, ethidium bromide and rhodamine 6G. MexCD-OprJ was not induced by norfloxacin, tetracycline, chloramphenicol, streptomycin, erythromycin or carbenicillin, although they are substrates for the pump. Cells of PAO1 showed increased resistance to norfloxacin when grown in the presence of the inducers of the mexCD-oprJ operon mentioned above. These results indicate that MexCD-OprJ plays an important role in intrinsic multidrug resistance in wild-type P. aeruginosa in hospitals where disinfectants are used frequently.

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页码：991 / 994

页数：4

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