NetPath: a public resource of curated signal transduction pathways

被引：330

作者：

Kandasamy, Kumaran ^{[1
,2
,3
]}

Mohan, S. Sujatha ^{[3
]}

Raju, Rajesh ^{[3
,4
]}

Keerthikumar, Shivakumar ^{[3
]}

Kumar, Ghantasala S. Sameer ^{[3
]}

Venugopal, Abhilash K. ^{[3
]}

Telikicherla, Deepthi ^{[3
]}

Navarro, J. Daniel ^{[3
]}

Mathivanan, Suresh ^{[3
]}

Pecquet, Christian

Gollapudi, Sashi Kanth ^{[3
]}

Tattikota, Sudhir Gopal ^{[3
]}

Mohan, Shyam ^{[3
]}

Padhukasahasram, Hariprasad ^{[3
]}

Subbannayya, Yashwanth ^{[3
]}

Goel, Renu ^{[3
]}

Jacob, Harrys K. C. ^{[1
,2
,3
]}

Zhong, Jun ^{[1
,2
]}

Sekhar, Raja ^{[3
]}

Nanjappa, Vishalakshi ^{[3
]}

Balakrishnan, Lavanya ^{[3
]}

Subbaiah, Roopashree ^{[3
]}

Ramachandra, Y. L. ^{[4
]}

Rahiman, B. Abdul ^{[4
]}

Prasad, T. S. Keshava ^{[3
]}

Lin, Jian-Xin ^{[5
]}

Houtman, Jon C. D. ^{[6
]}

Desiderio, Stephen ^{[7
]}

Renauld, Jean-Christophe ^{[8
,9
]}

Constantinescu, Stefan N. ^{[8
,9
]}

Ohara, Osamu ^{[10
,11
]}

Hirano, Toshio ^{[12
,13
,14
]}

Kubo, Masato ^{[15
,16
]}

Singh, Sujay ^{[17
]}

Khatri, Purvesh ^{[18
]}

Draghici, Sorin ^{[18
,19
]}

Bader, Gary D. ^{[20
,21
]}

Sander, Chris ^{[21
]}

Leonard, Warren J. ^{[5
]}

Pandey, Akhilesh ^{[1
,2
,22
]}

机构：

[1] Johns Hopkins Univ, McKusick Nathans Inst Genet Med, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Dept Biol Chem, Baltimore, MD 21205 USA

[3] Inst Bioinformat, Bangalore 560066, Karnataka, India

[4] Kuvempu Univ, Dept Biotechnol & Bioinformat, Jnanasahyadri 577451, Shimoga, India

[5] NHLBI, Lab Mol Immunol, NIH, Bethesda, MD 20892 USA

[6] Univ Iowa, Dept Microbiol, Carver Coll Med, Iowa City, IA 52242 USA

[7] Johns Hopkins Univ, Sch Med, Dept Mol Biol & Genet, Inst Cell Engn, Baltimore, MD 21205 USA

[8] Catholic Univ Louvain, Ludwig Inst Canc Res, Brussels Branch, B-1200 Brussels, Belgium

[9] Catholic Univ Louvain, Expt Med Unit, Christian de Duve Inst Cellular Pathol, B-1200 Brussels, Belgium

[10] RIKEN Yokohama Inst, Lab Immunogenom, RIKEN Res Ctr Allergy & Immunol, RIKEN Yokohama Inst, Kanagawa 2300045, Japan

[11] Kazusa DNA Res Inst, Dept Human Genome Technol, Chiba 2920818, Japan

[12] RIKEN Res Ctr Allergy & Immunol, Lab Cytokine Signaling, Kanagawa 2300045, Japan

[13] Osaka Univ, Grad Sch Frontier Biosci, Labs Dev Immunol, Osaka 5650871, Japan

[14] Osaka Univ, Grad Sch Med, Osaka 5650871, Japan

[15] Tokyo Univ Sci, Res Inst Biol Sci, Noda, Chiba 2780022, Japan

[16] RIKEN Yokohama Inst, Signal Network Team, RIKEN Res Ctr Allergy & Immunol, Kanagawa 2300045, Japan

[17] IMGENEX India Pvt Ltd, Bhubaneswar 92121, Orissa, India

[18] Wayne State Univ, Dept Comp Sci, Detroit, MI 48202 USA

[19] Wayne State Univ, Karmanos Canc Inst, Detroit, MI 48202 USA

[20] Univ Toronto, Banting & Best Dept Med Res, Terrence Donnelly Ctr Cellular & Biomol Res, Toronto, ON M5S 3E1, Canada

[21] Mem Sloan Kettering Canc Ctr, Computat Biol Ctr, New York, NY 10021 USA

[22] Johns Hopkins Univ, Dept Oncol, Baltimore, MD 21205 USA

来源：

GENOME BIOLOGY | 2010年 / 11卷 / 01期

基金：

美国国家卫生研究院;

关键词：

SYSTEMS-APPROACH; REPRESENTATION; NETWORKS; CELLS; PROLIFERATION; ENVIRONMENT; ACTIVATION; SOFTWARE; DATABASE; VITRO;

D O I：

10.1186/gb-2010-11-1-r3

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We have developed NetPath as a resource of curated human signaling pathways. As an initial step, NetPath provides detailed maps of a number of immune signaling pathways, which include approximately 1,600 reactions annotated from the literature and more than 2,800 instances of transcriptionally regulated genes - all linked to over 5,500 published articles. We anticipate NetPath to become a consolidated resource for human signaling pathways that should enable systems biology approaches.

引用

页数：9

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