An Efficient and Benign Antimicrobial Depot Based on Silver-Infused MoS2

被引：225

作者：

Cao, Fangfang ^{[1
,2
,3
]}

Ju, Enguo ^{[1
,2
,4
]}

Zhang, Yan ^{[1
,2
,4
]}

Wang, Zhenzhen ^{[1
,2
,4
]}

Liu, Chaoqun ^{[1
,2
,4
]}

Huang, Yanyan ^{[1
,2
,4
]}

Dong, Kai ^{[1
,2
,4
]}

Ren, Jinsong ^{[1
,2
]}

Qu, Xiaogang ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Rare Earth Resources Utilizat, Changchun 130022, Peoples R China

[2] Chinese Acad Sci, Changchun Inst Appl Chem, Lab Chem Biol, Changchun 130022, Peoples R China

[3] Univ Sci & Technol China, Hefei 230029, Anhui, Peoples R China

[4] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

来源：

ACS NANO | 2017年 / 11卷 / 05期

基金：

中国国家自然科学基金;

关键词：

antibacterial depot; molybdenum disulfide; silver nanoparticles; wound infection; negligible biotoxicity; ANTIBACTERIAL ACTIVITY; GRAPHENE OXIDE; KNOWLEDGE GAPS; NANOPARTICLES; NANOCOMPOSITE; NANOSHEETS; COMPOSITE; AGENT; FUNCTIONALIZATION; STABILITY;

D O I：

10.1021/acsnano.7b00343

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Silver nanoparticles (AgNPs) have been used as a broad-spectrum antimicrobial agent, whose toxicity originates from the localized release of Ag+ ions. However, the residual AgNPs core could generate potential risk to humans and waste of noble metals. Herein, we infused the cysteine-modified molybdenum disulfide with minimum Ag+ ions and coated with a layer of cationic polyelectrolyte to construct an efficient and benign antimicrobial depot. The system exhibited much enhanced broad-spectrum antibacterial activity compared with an equivalent amount of silver nitrate, owing to its increasing accessibility of released Ag+ to the cell walls of microorganisms. More importantly, the antibacterial system could be successfully applied to treat wound infection, while retaining high antibacterial activities, exhibiting negligible biotoxicity and avoiding the waste of Ag.

引用

页码：4651 / 4659

页数：9

共 53 条

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