Linking cognitive aging to alterations in dopamine neurotransmitter functioning: Recent data and future avenues

被引：293

作者：

Backman, Lars ^{[1
]}

Lindenberger, Ulman ^{[2
]}

Li, Shu-Chen ^{[2
]}

Nyberg, Lars ^{[3
,4
]}

机构：

[1] Karolinska Inst, Aging Res Ctr, S-11330 Stockholm, Sweden

[2] Max Planck Inst Human Dev & Educ, D-1000 Berlin, Germany

[3] Umea Univ, Dept Integrat Med Biol, S-90187 Umea, Sweden

[4] Umea Univ, Dept Radiat Sci, S-90187 Umea, Sweden

来源：

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | 2010年 / 34卷 / 05期

基金：

瑞典研究理事会;

关键词：

Aging; Cognition; Dopamine; Processing fluctuations; Multimodal imaging; Striatum; Working-memory training; POSITRON-EMISSION-TOMOGRAPHY; AGE-DEPENDENT DECLINE; WORKING-MEMORY; ADULT AGE; OLD-AGE; INTRAINDIVIDUAL VARIABILITY; RECEPTOR-BINDING; REACTION-TIME; HUMAN BRAIN; PERFORMANCE VARIABILITY;

D O I：

10.1016/j.neubiorev.2009.12.008

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Molecular-imaging studies of dopaminergic neurotransmission measure biomarkers of dopamine (DA), such as the DA transporter and D-1 and D-2 receptor densities in the living brain. These studies indicate that individual differences in DA functions are linked to cognitive performance irrespective of age, and serve as powerful mediators of age-related decline in executive functioning, episodic memory, and perceptual speed. This focused review targets several recent findings pertaining to these relationships. Specifically, we discuss novel evidence concerning (a) the role of DA in within-person cognitive variability; (b) age-related differences in DA release during cognitive processing; (c) DA release following cognitive training in younger and older adults; and (d) the relationship between DA and task-induced functional brain activity. Based on these lines of empirical inquiry, we outline a series of avenues for future research on aging, DA, and cognition. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：670 / 677

页数：8

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