Koschei the immortal and anti-aging drugs

被引：28

作者：

Blagosklonny, M. V. ^{[1
]}

机构：

[1] BLSC, Roswell Pk Canc Inst, Dept Cell Stress Biol, Buffalo, NY 14263 USA

来源：

CELL DEATH & DISEASE | 2014年 / 5卷

关键词：

EXTENDS LIFE-SPAN; HIGH-FAT DIET; HER-2/NEU TRANSGENIC MICE; HEPATIC INSULIN-RESISTANCE; TERM CALORIE RESTRICTION; ACUTE MYELOID-LEUKEMIA; AGE-RELATED DISEASES; MAMMALIAN TARGET; COLORECTAL-CANCER; MTOR-INHIBITOR;

D O I：

10.1038/cddis.2014.520

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

In Slavic folklore, Koschei the Immortal was bony, thin and lean. Was his condition caused by severe calorie restriction (CR)? CR deactivates the target of rapamycin pathway and slows down aging. But the life-extending effect of severe CR is limited by starvation. What if Koschei's anti-aging formula included rapamycin? And was rapamycin (or another rapalog) combined with commonly available drugs such as metformin, aspirin, propranolol, angiotensin II receptor blockers and angiotensin-converting enzyme inhibitors.

引用

页码：e1552 / e1552

页数：7

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