A new silicon detector for microdosimetry applications in proton therapy

被引:64
作者
Rosenfeld, AB [1 ]
Bradley, PD
Cornelius, I
Kaplan, GI
Allen, BJ
Flanz, JB
Goitein, M
Van Meerbeeck, A
Schubert, J
Bailey, J
Takada, Y
Maruhashi, A
Hayakawa, Y
机构
[1] Univ Wollongong, Dept Engn Phys, Wollongong, NSW 2522, Australia
[2] Harvard Univ, Sch Med, NPTC, Boston, MA 02114 USA
[3] Univ Tsukuba, Tsukuba, Ibaraki 305, Japan
基金
英国医学研究理事会;
关键词
D O I
10.1109/23.872983
中图分类号
TM [电工技术]; TN [电子技术、通信技术];
学科分类号
0808 ; 0809 ;
摘要
A silicon-on-insulator diode array with a sensitive depth of 10 microns has been developed for microdosimetry in proton therapy. The detector was coupled to a radiation-hard charge sensitive amplifier with the probe assembly capable of measuring-an LET down to 1.2 keV/mu m. The device has been successfully tested at two proton therapy centers: The 230 MeV Northeastern Proton Therapy Center, Boston and the 250 MeV Proton Medical Research Center at Tsukuba, Japan. The:device offers much improved spatial resolution compared with a-proportional gas counter particularly in the critical high dose region around the proton Bragg peak. Due to its small cross-sectional area (0.04 cm(2)) measurements may also be made in facilities with short high intensity beams.
引用
收藏
页码:1386 / 1394
页数:9
相关论文
共 23 条
[1]  
[Anonymous], 1993, STOPPING POWERS RANG
[2]   Biophysical investigations of therapeutic proton beams [J].
Becker, R ;
Bienen, J ;
Carl, U ;
Cloth, P ;
Dellert, M ;
Druke, V ;
Eyrich, W ;
Filges, D ;
Fritsch, M ;
Hauffe, J ;
Hoffmann, W ;
Kobus, H ;
Maier, R ;
Moosburger, M ;
Olko, P ;
Paganetti, H ;
Peterson, HP ;
Schmitz, T ;
Schwenke, K ;
Sperl, R .
RADIATION PROTECTION DOSIMETRY, 1997, 70 (1-4) :485-492
[3]   Charge collection and radiation hardness of a SOI microdosimeter for medical and space applications [J].
Bradley, PD ;
Rosenfeld, AB ;
Lee, KK ;
Jamieson, DN ;
Heiser, G ;
Satoh, S .
IEEE TRANSACTIONS ON NUCLEAR SCIENCE, 1998, 45 (06) :2700-2710
[4]   Tissue equivalence correction for silicon microdosimetry detectors in boron neutron capture therapy [J].
Bradley, PD ;
Rosenfeld, AB .
MEDICAL PHYSICS, 1998, 25 (11) :2220-2225
[5]   Performance of silicon microdosimetry detectors in boron neutron capture therapy [J].
Bradley, PD ;
Rosenfeld, AB ;
Allen, B ;
Coderre, J ;
Capala, J .
RADIATION RESEARCH, 1999, 151 (03) :235-243
[6]  
BRADLEY PD, 1998, 8 INT S NEUTR CAPT T
[7]   Microdosimetric studies on the Orsay proton synchrocyclotron at 73 and 200 MeV [J].
Cosgrove, VP ;
Delacroix, S ;
Green, S ;
Mazal, A ;
Scott, MC .
RADIATION PROTECTION DOSIMETRY, 1997, 70 (1-4) :493-496
[8]  
COSGROVE VP, 1990, RADIAT PROT DOSIM, V44, P405
[9]   Microdosimetry spectra of the Loma Linda proton beam and relative biological effectiveness comparisons [J].
Coutrakon, G ;
Cortese, J ;
Ghebremedhin, A ;
Hubbard, J ;
Johanning, J ;
Koss, P ;
Maudsley, G ;
Slater, CR ;
Zuccarelli, C ;
Robertson, J .
MEDICAL PHYSICS, 1997, 24 (09) :1499-1506
[10]  
DELANEY CFG, 1992, RAD DETECTORS PHYSIC, V1