Differential effects of COMT on gait and executive control in aging

被引:41
作者
Holtzer, R. [1 ,2 ]
Ozelius, L. [4 ]
Xue, X. [3 ]
Wang, T. [3 ]
Lipton, R. B. [2 ,3 ]
Verghese, J. [1 ]
机构
[1] Yeshiva Univ, Albert Einstein Coll Med, Dept Neurol, Bronx, NY 10461 USA
[2] Yeshiva Univ, Albert Einstein Coll Med, Ferkauf Grad Sch Psychol, Bronx, NY 10461 USA
[3] Yeshiva Univ, Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10461 USA
[4] Mt Sinai Sch Med, Dept Genet & Genom Sci, New York, NY 10029 USA
关键词
Gait velocity; COMT; Cognition; Aging; Attention; Executive function; CATECHOL-O-METHYLTRANSFERASE; WORKING-MEMORY; HUMAN BRAIN; CONVENTIONAL NEUROLEPTICS; VAL(158)MET POLYMORPHISM; FUNCTIONAL POLYMORPHISM; COGNITIVE-PROCESSES; PREFRONTAL CORTEX; DOPAMINE RELEASE; DOWN-REGULATION;
D O I
10.1016/j.neurobiolaging.2008.05.011
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Walking speed is associated with attention and executive control processes subserved by the prefrontal cortex. Because polymorphisms in catechol-O-methyltransferase (COMT) influence these cognitive processes we hypothesized that the same polymorphisms may influence gait velocity. We examined the associations between the Val(158)Met polymorphism in COMT and gait velocity as well as attention and executive function. Participants were 278 non-demented older adults. The results revealed that methionine (Met)/valine (Val) was associated with faster gait velocity. This association can be explained by the putative role of the Val allele in regulating tonic dopamine release in the striatum. In contrast, Met/Met was associated with better attention and executive function. Stratification by gender revealed that the association between COMT genotype and gait was significant only in men. Conversely, the association between COMT genotype and attention and executive function was significant only in women. These findings suggest a differential effect in relating the Val(158)Met polymorphism to gait and to cognitive function while supporting the previously described sexual dimorphism in the phenotypic expressions of COMT. (C) 2008 Elsevier Inc. All rights reserved.
引用
收藏
页码:523 / 531
页数:9
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