Eukaryotic translation initiation factors and regulators

被引：276

作者：

Sonenberg, N

Dever, TE

机构：

[1] McGill Univ, Dept Biochem, Montreal, PQ H3G 1Y6, Canada

[2] McGill Univ, McGill Canc Ctr, Montreal, PQ H3G 1Y6, Canada

[3] NICHHD, Lab Gene Regulat & Dev, NIH, Bethesda, MD 20892 USA

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 2003年 / 13卷 / 01期

基金：

加拿大健康研究院;

关键词：

D O I：

10.1016/S0959-440X(03)00009-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Significant progress has been made over the past several years on structural studies of the eukaryotic translation initiation factors that facilitate the assembly of a translation-competent ribosome at the initiation codon of an mRNA. These structural studies have revealed the repeated use of a set of common structural folds, highlighted the evolutionary conservation of the translation apparatus, and provided insight into the mechanism and regulation of cellular and viral protein synthesis.

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收藏

页码：56 / 63

页数：8

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