A CpG oligodeoxynucleotide inducing anti-coxsackie B3 virus activity in human peripheral blood mononuclear cells

被引：13

作者：

Cong, Zhongyi

Wan, Min

Wu, Xiuli

Wang, Li

Hu, Xiaoping

Yang, Fenglei

Bao, Musheng

Zhang, Xuesong

Chen, Jianzhu

Wang, Liying

Yu, Yongli

机构：

[1] Jilin Univ, Coll Basic Med, Dept Immunol, Changchun, Peoples R China

[2] Jilin Univ, Coll Basic Med, Dept Biol Mol, Changchun, Peoples R China

[3] Blood Ctr Jilin Prov, Changchun, Peoples R China

[4] MIT, Ctr Canc Res, Dept Biol, Cambridge, MA 02139 USA

来源：

FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY | 2007年 / 51卷 / 01期

关键词：

CpG ODN; coxsackie virus; IFN-alpha; IFN-beta; IFN-omega; IFN-gamma;

D O I：

10.1111/j.1574-695X.2007.00266.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Coxsackie B3 virus (CVB3) is the most significant pathogen causing myocarditis in humans, and antiviral therapy would be most effective in the early stages of the disease. Here we provide evidence that BW001, a C-type CpG oligodeoxynucleotide, induces anti-CVB3 activity in human peripheral blood mononuclear cells (PBMCs). In parallel, we have demonstrated that BW001 induces human PBMCs to express mRNAs of multiple types of interferon (IFN), including IFN-alpha, IFN-beta, IFN-omega and IFN-gamma, and to express mRNAs of at least 11 subtypes of IFN-alpha. The induced IFNs may contribute to the anti-CVB3 activity. The results suggest that BW001 could be developed into a medication with the potential to treat CVB3 infectious diseases by inducing natural mixed IFNs.

引用

页码：26 / 34

页数：9

共 52 条

[1]

[Anonymous], 2001, Anal Biochem

[2]

Local delivery of CpG oligodeoxynucleotides induces rapid changes in the genital mucosa and inhibits replication, but not entry, of herpes simplex virus type 2 [J].