Mechanisms of DNA damage by leinamycin

被引：69

作者：

Gates, KS ^{[1
]}

机构：

[1] Univ Missouri, Dept Chem, Columbia, MO 65211 USA

[2] Univ Missouri, Dept Biochem, Columbia, MO 65211 USA

来源：

CHEMICAL RESEARCH IN TOXICOLOGY | 2000年 / 13卷 / 10期

关键词：

D O I：

10.1021/tx000089m

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：953 / 956

页数：4

共 38 条

[1]

[Anonymous], RUSS CHEM REV

[2] Thiol-mediated DNA alkylation by the novel antitumor antibiotic leinamycin [J].

Asai, A ;

Hara, M ;

Kakita, S ;

Kanda, Y ;

Yoshida, M ;

Saito, H ;

Saitoh, Y .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996, 118 (28) :6802-6803

[3] Thiol-independent DNA cleavage by a leinamycin degradation product [J].

Asai, A ;

Saito, H ;

Saitoh, Y .

BIOORGANIC & MEDICINAL CHEMISTRY, 1997, 5 (04) :723-729

[4] 1,2-Dithiolan-3-one 1-oxides: A class of thiol-activated DNA-Cleaving agents that are structurally related to the natural product leinamycin [J].

Behroozi, SJ ;

Kim, W ;

Dannaldson, J ;

Gates, KS .

BIOCHEMISTRY, 1996, 35 (06) :1768-1774

[5] REACTION OF N-PROPANETHIOL WITH 3H-1,2-BENZODITHIOL-3-ONE 1-OXIDE AND 5,5-DIMETHYL-1,2-DITHIOLAN-3-ONE 1-OXIDE - STUDIES RELATED TO THE REACTION OF ANTITUMOR ANTIBIOTIC LEINAMYCIN WITH DNA [J].

BEHROOZI, SJ ;

KIM, WK ;

GATES, KS .

JOURNAL OF ORGANIC CHEMISTRY, 1995, 60 (13) :3964-3966

[6] Crystal structure of 3H-1,2-benzodithiol-3-one 1-oxide [J].

Behroozi, SJ ;

Barnes, CL ;

Gates, KS .

JOURNAL OF CHEMICAL CRYSTALLOGRAPHY, 1998, 28 (09) :689-691

[7] DEMONSTRATION OF NUCLEAR COMPARTMENTALIZATION OF GLUTATHIONE IN HEPATOCYTES [J].

BELLOMO, G ;

VAIRETTI, M ;

STIVALA, L ;

MIRABELLI, F ;

RICHELMI, P ;

ORRENIUS, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (10) :4412-4416

[8] Thiol-dependent DNA cleavage by 3H-1,2-Benzodithiol-3-one 1,1-dioxide [J].

Breydo, L ;

Gates, KS .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2000, 10 (09) :885-889

[9]

BRYDON A, 1972, INT J SULFUR CHEM A, V2, P289

[10] DNA cleavage by 7-methylbenzopentathiepin: A simple analog of the antitumor antibiotic varacin [J].

Chatterji, T ;

Gates, KS .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1998, 8 (05) :535-538

← 1 2 3 4 →