Redundant Control of Adipogenesis by Histone Deacetylases 1 and 2

被引：108

作者：

Haberland, Michael ^{[1
]}

Carrer, Michele ^{[1
]}

Mokalled, Mayssa H. ^{[1
]}

Montgomery, Rusty L. ^{[1
]}

Olson, Eric N. ^{[1
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Mol Biol, Dallas, TX 75390 USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2010年 / 285卷 / 19期

基金：

美国国家卫生研究院;

关键词：

CHAIN FATTY-ACIDS; INHIBITORS; DIFFERENTIATION; HYPERTROPHY; ROLES;

D O I：

10.1074/jbc.M109.081679

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Adipocyte differentiation is a well defined process that is under the control of transcriptional activators and repressors. We show that histone deacetylase (HDAC) inhibitors efficiently block adipocyte differentiation in vitro. This effect is specific to adipogenesis, as another mesenchymal differentiation process, osteoblastogenesis, is enhanced upon HDAC inhibition. Through the systematic genetic deletion of HDAC genes in cultured mesenchymal precursor cells, we show that deletion of HDAC1 and HDAC2 leads to reduced lipid accumulation, revealing redundant and requisite roles of these class I HDACs in adipogenesis. These findings unveil a previously unrecognized role for HDACs in the control of adipogenesis.

引用

页码：14663 / 14670

页数：8

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