Highly regioselective radical alkylation of 3-substituted pyrroles

被引：30

作者：

Guadarrama-Morales, Oscar

Mendez, Francisco

Miranda, Luis D.

机构：

[1] Univ Nacl Autonoma Mexico, Inst Quim, Mexico City 04510, DF, Mexico

[2] Univ Autonoma Metropolitana Iztapalapa, Dept Quim, Div Ciencias Basicas & Ingn, Mexico City 09340, DF, Mexico

来源：

TETRAHEDRON LETTERS | 2007年 / 48卷 / 26期

关键词：

D O I：

10.1016/j.tetlet.2007.04.146

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

It is reported that the intermolecular oxidative radical substitution on 3-substituted pyrroles gives the 2,3-disubstituted pyrroles in a highly regioselective manner. This behavior is explained on the basis of the relative stabilities of the intermediate radicals formed in the process. The methodology reported herein represents a direct entry into 2,3-disubstituted pyrroles, which might be used to construct more complex molecules. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：4515 / 4518

页数：4

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