Manipulation of innate immunity by bacterial pathogens

被引：36

作者：

Portnoy, DA ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94703 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2005年 / 17卷 / 01期

关键词：

D O I：

10.1016/j.coi.2004.11.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The past decade has witnessed tremendous growth in two related fields: innate immunity and microbial pathogenesis. Many pathogens have evolved mechanisms to infect their hosts in the face of a fully functional innate immune system, and there are numerous examples by which pathogens avoid recognition and/or suppress inflammation. In this review, I suggest that pathogens not only survive the innate immune response, but use it to promote their pathogenesis.

引用

页码：25 / 28

页数：4

共 38 条

[1] Phagocytosis and the inflammatory response [J].

Aderem, A .

JOURNAL OF INFECTIOUS DISEASES, 2003, 187 :S340-S345

[2] Mice lacking the type I interferon receptor are resistant to Listeria monocytogenes [J].

Auerbuch, V ;

Brockstedt, DG ;

Meyer-Morse, N ;

O'Riordan, M ;

Portnoy, DA .

JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 200 (04) :527-533

[3] Inferences, questions and possibilities in toll-like receptor signalling [J].

Beutler, B .

NATURE, 2004, 430 (6996) :257-263

[4] Interleukin-10 and inhibition of innate immunity to yersiniae: Roles of Yops and LcrV (V antigen) [J].

Brubaker, RR .

INFECTION AND IMMUNITY, 2003, 71 (07) :3673-3681

[5] Type I interferon sensitizes lymphocytes to apoptosis and reduces resistance to listeria infection [J].

Carrero, JA ;

Calderon, B ;

Unanue, ER .

JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 200 (04) :535-540

[6] Bacterial invasion: The paradigms of enteroinvasive pathogens [J].

Cossart, P ;

Sansonetti, PJ .

SCIENCE, 2004, 304 (5668) :242-248

[7] Two msbB genes encoding maximal acylation of lipid A are required for invasive Shigella flexneri to mediate inflammatory rupture and destruction of the intestinal epithelium [J].

d'Hauteville, H ;

Khan, S ;

Maskell, DJ ;

Kussak, A ;

Weintraub, A ;

Mathison, J ;

Ulevitch, RJ ;

Wuscher, N ;

Parsot, C ;

Sansonetti, PJ .

JOURNAL OF IMMUNOLOGY, 2002, 168 (10) :5240-5251

[8] Porphyromonas gingivalis lipopolysaccharide contains multiple lipid a species that functionally interact with both toll-like receptors 2 and 4 [J].

Darveau, RP ;

Pham, TTT ;

Lemley, K ;

Reife, RA ;

Bainbridge, BW ;

Coats, SR ;

Howald, WN ;

Way, SS ;

Hajjar, AM .

INFECTION AND IMMUNITY, 2004, 72 (09) :5041-5051

[9] Mycobacterium tuberculosis inhibits macrophage responses to IFN-γ through myeloid differentiation factor 88-dependent and -independent mechanisms [J].

Fortune, SM ;

Solache, A ;

Jaeger, A ;

Hill, PJ ;

Belisle, JT ;

Bloom, BR ;

Rubin, EJ ;

Ernst, JD .

JOURNAL OF IMMUNOLOGY, 2004, 172 (10) :6272-6280

[10] Tuberculosis [J].

Frieden, TR ;

Sterling, TR ;

Munsiff, SS ;

Watt, CJ ;

Dye, C .

LANCET, 2003, 362 (9387) :887-899

← 1 2 3 4 →