Concept transfer - From genetic instruction to molecular logic

被引：10

作者：

Cheah, IK ^{[1
]}

Langford, SJ ^{[1
]}

Latter, MJ ^{[1
]}

机构：

[1] Monash Univ, Sch Chem, Clayton, Vic 3168, Australia

来源：

SUPRAMOLECULAR CHEMISTRY | 2005年 / 17卷 / 1-2期

关键词：

molecular logic; peptide nucleic acids; AMPA receptor; amyotrophic lateral sclerosis; DNA-based logic;

D O I：

10.1080/10610270412331328862

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This review describes the advances made in utilizing the unique recognition and structural characteristics of DNA to perform Boolean algebra using complex logic functions such as AND, XOR, NAND and INHIBIT based on chemical or photonic inputs. A comparison of these results to the action of novel 12-mer antisense peptide nucleic acid (PNA) constructs targeting the AMPA receptor in live motor neuron hybrids (NSC34) is made. In this case, a NOT function is displayed through down-regulation of the GluR3 subunit, a result that impedes other cellular chemical processes. The consequence of cellular logic based on chemical inputs such as PNAs and their utilization as whole-cell machines whose biological output is chemical input-dependent is discussed briefly.

引用

页码：121 / 128

页数：8

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