Magnetic and temperature-sensitive release gels from supramolecular polymers

被引:100
作者
Binder, Wolfgang H.
Petraru, Laura
Roth, Thomas
Groh, Peter W.
Palfi, Viktoria
Keki, Sandor
Ivan, Bela
机构
[1] Vienna Univ Technol, Inst Appl Synthet Chem, Div Macromol Chem, A-1060 Vienna, Austria
[2] Hungarian Acad Sci, Chem Res Ctr, Inst Mat & Environm Chem, Dept Polymer Chem & Mat Sci, H-1525 Budapest, Hungary
[3] Univ Debrecen, Dept Appl Chem, H-4010 Debrecen, Hungary
关键词
D O I
10.1002/adfm.200601084
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Supramolecular gels consisting of trivalent polyisobutylene and bivalent poly(ethylene oxide) are generated. Strong hydrogen bonding interactions, affixed to the end-group moieties of the respective polymers (binding constant K-assn = 10(5) M-1), serve as molecular glue, leading to the formation of weak gels. Two different gels were prepared: one, with a short telechelic poly(ethylene glycol) (PEG) segment (gel A), and one with a longer PEG segment (number-average molecular weight M-n = 2000 g mol(-1)) (gel B). Both gels show a significant increase in viscosity upon mixing of the two polymeric components, with a lag time of several minutes, indicative of nucleation mechanisms as the formation principle. However, only gel A displays classical gel-like behavior, with a loss modulus G' larger than the storage modulus G '' after formation. Both gels display microphase-separated behavior with a spacing between 4-5 nm as probed via small-angle X-ray scattering (SAXS) and transmission electron microscopy (TEM) measurements. The incorporation of magnetic nanoparticles (Fe2O3; radius r = 3.5 nm) is successfully achieved, generating new magnetic gels with strongly thermoresponsive properties, displaying a strong temperature-dependent release profile of included dye molecules. Magnetic measurements indicate a superparamagnetic behavior of the incorporated nanoparticles, prospecting the application as magneto-sensitive delivery gels for pharmaceutical purposes.
引用
收藏
页码:1317 / 1326
页数:10
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