Investigation of the silylation of ephedrines using N-methyl-N-trimethylsilyl-trifluoroacetamide

被引：13

作者：

Forsdahl, G ^{[1
]}

Gmeiner, G ^{[1
]}

机构：

[1] Austrian Res Ctr Seibersdorf Res GmbH, Dept Environm Analyt, Doping Control Lab, A-2444 Seibersdorf, Austria

来源：

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | 2004年 / 811卷 / 02期

关键词：

ephedrine; pseudoephedrine; cathine; norephedrine; methylephedrine; derivatisation; doping; silylation; N-methyl-N-timethylsilyltrifluoroacetamide;

D O I：

10.1016/j.chromb.2004.09.002

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

This paper describes a gas chromatography (GC)-mass spectrometry (MS) method for the simultaneous quantification of ephedrine, pseudoephedrine, cathine, norephedrine and methylephedrine in urine. The sample preparation step includes solid phase extraction and derivatisation with N-methyl-N-trimethylsilyl-trifluoroacetamide (MSTFA). An evaluation of various silylation conditions compatible with screening methods in doping control analysis is presented. The method was found to be well suited for quantification of ephedrines in doping control. (C) 2004 Elsevier B.V. All rights reserved.

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收藏

页码：201 / 208

页数：8

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