In vitro measurements of mucoadhesive properties of six types of pectin

被引：40

作者：

Hagesaether, Ellen ^{[1
]}

Sande, Sverre Arne ^{[1
]}

机构：

[1] Univ Oslo, Sch Pharm, Dept Pharm, N-0316 Oslo, Norway

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 2007年 / 33卷 / 04期

关键词：

mucoadhesion; pectin; texture analyzer; degree of methoxylation; amidation;

D O I：

10.1080/03639040600920630

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The objective of this study was to measure and compare the specific- and general mucin interaction of six pectin types from three manufacturers, differing mainly in the degree of methoxylation and degree of amidation. Mucoadhesive properties were measured using a texture analyzer. It was found that an intermediate degree of methoxylation (35 and 36%) improved the specific mucin interaction. Amidation did not increase mucin interaction. Samples from different manufacturers did not alter these conclusions. This study indicates that the general classification of pectin as a poor mucoadhesive, without differentiating between the amount and type of substituents, probably is an oversimplification.

引用

页码：417 / 425

页数：9

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