Emerging paradigms of regulated microRNA processing

被引：209

作者：

Newman, Martin A. ^{[1
]}

Hammond, Scott M. ^{[1
]}

机构：

[1] Univ N Carolina, Lineberger Comprehens Canc Ctr, Dept Cell & Dev Biol, Chapel Hill, NC 27599 USA

来源：

GENES & DEVELOPMENT | 2010年 / 24卷 / 11期

基金：

美国国家卫生研究院;

关键词：

Drosha; KSRP; Lin28; miRNA; microRNA; microprocessor; BOX RNA HELICASES; POSTTRANSCRIPTIONAL REGULATION; BINDING-PROTEIN; TRANSCRIPTIONAL COACTIVATOR; LET-7; MICRORNA; COMPLEX; P68; BIOGENESIS; LIN28; MODULATION;

D O I：

10.1101/gad.1919710

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

MicroRNAs (miRNAs) modulate a broad range of gene expression patterns during development and tissue homeostasis, and in the pathogenesis of disease. The exquisite spatio-temporal control of miRNA abundance is made possible, in part, by regulation of the miRNA biogenesis pathway. In this review, we discuss two emerging paradigms for post-transcriptional control of miRNA expression. One paradigm centers on the Microprocessor, the protein complex essential for maturation of canonical miRNAs. The second paradigm is specific to miRNA families, and requires interaction between RNA-binding proteins and cis-regulatory sequences within miRNA precursor loops.

引用

收藏

页码：1086 / 1092

页数：7

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